Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Lodelaben is a human neutrophil elastase inhibitor with an IC50 and Ki of 0.5 and 1.5 μM, respectively.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 6-8 weeks | $ 1,520.00 | |
50 mg | 6-8 weeks | $ 1,980.00 | |
100 mg | 6-8 weeks | $ 2,500.00 |
Description | Lodelaben is a human neutrophil elastase inhibitor with an IC50 and Ki of 0.5 and 1.5 μM, respectively. |
Targets&IC50 | Elastase:(ki)1.5 μM , Elastase:0.5 μM |
In vitro | Results indicate that the inhibition of human neutrophil elastase (HNE) by Lodelaben is non-competetive.?Lodelaben is not inhibitory at 10 μM with the synthetic substrates or at 5 μM vith Azocoll.?Pseudomonas aeruginosa elastase, a metallo-protease is not inhibited by Lodelaben.?Cathepsin G activity, however, is inhibited by Lodelaben, with an IC50 of approximately 2.5 μM, with Azocoll as substrate[1]. |
In vivo | The mean pulmonary artery pressures in both the saline/vehicle and saline/Lodelaben groups were comparable, at 16.4±1.1 and 17.4±0.9 mm Hg, respectively. However, the mean pressure significantly increased in the monocrotaline/vehicle group to 27.5±0.8 mm Hg. Notably, Lodelaben treatment in monocrotaline-administered rats markedly reduced the pressure to 21.00±1.6 mm Hg (p<0.05). In terms of vascular muscularization at the alveolar wall level, saline-treated rats, regardless of Lodelaben administration, demonstrated minimal muscularization (1.9±1.4% and 0.4±0.4%, respectively). Conversely, Lodelaben administration in monocrotaline-treated rats significantly lowered the percentage of muscularized alveolar wall arteries to 10.0±3.6%[2], indicating a protective effect of Lodelaben against monocrotaline-induced vascular alterations. |
Synonyms | SC-39026, Declaben |
Molecular Weight | 425.04 |
Formula | C25H41ClO3 |
CAS No. | 111149-90-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Lodelaben 111149-90-7 Others SC39026 SC-39026 Declaben SC 39026 inhibitor inhibit