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LY411575

Catalog No. T6063    CAS 209984-57-6   

LY411575, a potent γ-secretase inhibitor, is with IC50 of 0.078 nM in the membrane and 0.082 nM in cell-based. It also suppresses Notch clevage with IC50 of 0.39 nM.

Pack Size Availability Price/USD Quantity
2 mg In stock 50.00
5 mg In stock 70.00
10 mg In stock 120.00
25 mg In stock 264.00
50 mg In stock 480.00
100 mg Inquiry 730.00
1 mL * 10 mM (in DMSO) In stock 70.00
Bulk Size: Please Quote for Discount Please Quote for Bulk Size
Biological Activity:

Product Description:

LY411575, a potent γ-secretase inhibitor, is with IC50 of 0.078 nM in the membrane and 0.082 nM in cell-based. It also suppresses Notch clevage with IC50 of 0.39 nM.

Receptor:

Notch S3 cleavage; γ secretase (cell-based); γ secretase (membrane-based);

Chemical Information:
Molecular Weight 479.48
Formula C26H23F2N3O4
CAS Number 209984-57-6
Solubility

DMSO: 88 mg/mL (183.5 mM)

Ethanol: 11 mg/mL (22.9 mM)

Water: <1 mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )
Storage store at -80°C
Remark For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ℃ for several month.
Technical Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store Products, and issues that need special attention for cell-based assays and animal experiments.

Reference
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