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LMP744

Catalog No. T11872 CAS 308246-52-8

Synonyms: NSC706744, MJ-III65

LMP744 is a DNA intercalator and Topoisomerase I (Top1) inhibitor with antitumor activity.

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LMP744, CAS 308246-52-8

Pack Size	Availability	Price/USD
25 mg	6-8 weeks	$ 736.00
50 mg	6-8 weeks	$ 957.00
100 mg	6-8 weeks	$ 1,440.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

Storage & Solubility Information

Description	LMP744 is a DNA intercalator and Topoisomerase I (Top1) inhibitor with antitumor activity.
In vitro	LMP744 (0.1-5 μM, 3 days) induces dose-dependent accumulation of cells in the S and G2 phases of the cell cycle[2].The GI50 value of LMP744 for NCI60 cells is 0.1 μM[2].
In vivo	LMP744 ?(10-50 mg/kg) administered i.v. push once a week for 4 weeks in nude mice moderately actives against FaDu tumor xenografts??and human A253 without significant toxicity[1].

Synonyms	NSC706744, MJ-III65
Molecular Weight	452.46
Formula	C24H24N2O7
CAS No.	308246-52-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Antony S, et al. Cellular topoisomerase I inhibition and antiproliferative activity by MJ-III-65 (NSC 706744), an indenoisoquinoline topoisomerase I poison. Mol Pharmacol. 2005 Feb;67(2):523-30. 2. Antony S, et al. Novel indenoisoquinolines NSC 725776 and NSC 724998 produce persistent topoisomerase I cleavage complexes and overcome multidrug resistance. Cancer Res. 2007 Nov 1;67(21):10397-405.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

LMP744 308246-52-8 Others LMP-744 NSC-706744 LMP 744 NSC 706744 NSC706744 MJ-III65 inhibitor inhibit

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