Powder: -20°C for 3 years | In solvent: -80°C for 1 year
LAT1-IN-1 (BCH) (BCH) significantly inhibit cellular uptake of amino acids and mTOR phosphorylation, which induces the suppression of cancer growth and apoptosis. is a selective and competitive inhibitor of large neutral amino acid transporter 1 (LAT1).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | In stock | $ 36.00 | |
50 mg | In stock | $ 51.00 |
Description | LAT1-IN-1 (BCH) (BCH) significantly inhibit cellular uptake of amino acids and mTOR phosphorylation, which induces the suppression of cancer growth and apoptosis. is a selective and competitive inhibitor of large neutral amino acid transporter 1 (LAT1). |
In vitro | LAT1-IN-1 (30 mM; 0-24 hours; KYSE30 and KYSE150 cells) treatment decreases phosphorylation of 4E-BP1 and p70S6K at 30 minutes and the decrease is continued for 24 hours. The amount of mTOR, 4E-BP1, and p70S6K proteins is slightly decreased.LAT1-IN-1 (1-100 mM;?3 days;?KYSE30 and KYSE150 esophageal cancer cells) treatment suppresses cell proliferation in a dose-dependent manner.?LAT1-IN-1 (30 mM;?24 and 48 hours;?KYSE30 and KYSE150 cells) treatment significantly increases cell population in the G0/G1 phase in both KYSE30 and KYSE150 cells, indicating that LAT1-IN-1 induces cell cycle arrest at G1 phase. |
In vivo | LAT1-IN-1 (200 mg/kg;?intravenous injection;?daily;?for 14 days;?male BALB/c nude mice) treatment significantly delays tumor growth and decreases glucose metabolism, indicating that LAT1 inhibition potentially suppresses esophageal cancer growth in vivo. |
Synonyms | BCH |
Molecular Weight | 155.19 |
Formula | C8H13NO2 |
CAS No. | 20448-79-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 12.5 mg/mL (80.55 mM), sonification is recommended.
DMSO: < 1 mg/mL, insoluble or slightly soluble
You can also refer to dose conversion for different animals. More
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LAT1-IN-1 20448-79-7 Apoptosis Others LAT-1-IN-1 inhibit LAT1 IN 1 LAT1IN1 BCH Inhibitor inhibitor