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LAT1-IN-1

Catalog No. T11820   CAS 20448-79-7
Synonyms: BCH

LAT1-IN-1 (BCH) (BCH) significantly inhibit cellular uptake of amino acids and mTOR phosphorylation, which induces the suppression of cancer growth and apoptosis. is a selective and competitive inhibitor of large neutral amino acid transporter 1 (LAT1).

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LAT1-IN-1 Chemical Structure
LAT1-IN-1, CAS 20448-79-7
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25 mg In stock $ 36.00
50 mg In stock $ 51.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description LAT1-IN-1 (BCH) (BCH) significantly inhibit cellular uptake of amino acids and mTOR phosphorylation, which induces the suppression of cancer growth and apoptosis. is a selective and competitive inhibitor of large neutral amino acid transporter 1 (LAT1).
In vitro LAT1-IN-1 (30 mM; 0-24 hours; KYSE30 and KYSE150 cells) treatment decreases phosphorylation of 4E-BP1 and p70S6K at 30 minutes and the decrease is continued for 24 hours. The amount of mTOR, 4E-BP1, and p70S6K proteins is slightly decreased.LAT1-IN-1 (1-100 mM;?3 days;?KYSE30 and KYSE150 esophageal cancer cells) treatment suppresses cell proliferation in a dose-dependent manner.?LAT1-IN-1 (30 mM;?24 and 48 hours;?KYSE30 and KYSE150 cells) treatment significantly increases cell population in the G0/G1 phase in both KYSE30 and KYSE150 cells, indicating that LAT1-IN-1 induces cell cycle arrest at G1 phase.
In vivo LAT1-IN-1 (200 mg/kg;?intravenous injection;?daily;?for 14 days;?male BALB/c nude mice) treatment significantly delays tumor growth and decreases glucose metabolism, indicating that LAT1 inhibition potentially suppresses esophageal cancer growth in vivo.
Synonyms BCH
Molecular Weight 155.19
Formula C8H13NO2
CAS No. 20448-79-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 12.5 mg/mL (80.55 mM), sonification is recommended.

DMSO: < 1 mg/mL, insoluble or slightly soluble

TargetMolReferences and Literature

1. Ohshima Y, et al. Efficacy of system l amino acid transporter 1 inhibition as a therapeutic target in esophageal squamous cell carcinoma. Cancer Sci. 2016 Oct;107(10):1499-1505. 2. Singh N, et al. Discovery of Potent Inhibitors for the Large Neutral Amino Acid Transporter 1 (LAT1) by Structure-Based Methods. Int J Mol Sci. 2018 Dec 21;20(1). 3. Wang Q, et al. L-type amino acid transport and cancer: targeting the mTORC1 pathway to inhibit neoplasia. Am J Cancer Res. 2015 Mar 15;5(4):1281-94. eCollection 2015.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Active Compound Library Apoptosis Compound Library Bioactive Compound Library Inhibitor Library Bioactive Compounds Library Max Anti-Cancer Compound Library NO PAINS Compound Library

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Keywords

LAT1-IN-1 20448-79-7 Apoptosis Others LAT-1-IN-1 inhibit LAT1 IN 1 LAT1IN1 BCH Inhibitor inhibitor

 

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