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JPH203 dihydrochloride

Catalog No. T11727 CAS 1597402-27-1

Synonyms: KYT-0353 dihydrochloride

JPH203 dihydrochloride (KYT-0353 dihydrochloride) is a tyrosine analog, acts as a selective inhibitor of L-type amino acid transporter 1 (LAT1), and is used in cancer research.

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JPH203 dihydrochloride Chemical Structure

JPH203 dihydrochloride, CAS 1597402-27-1

Pack Size	Availability	Price/USD
1 mg	In stock	$ 109.00
2 mg	In stock	$ 162.00
5 mg	In stock	$ 198.00
10 mg	In stock	$ 297.00
25 mg	In stock	$ 483.00
50 mg	In stock	$ 690.00
100 mg	In stock	$ 982.00
1 mL * 10 mM (in DMSO)	In stock	$ 297.00

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Purity: 97.28%

Purity: 95.39%

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Description	JPH203 dihydrochloride (KYT-0353 dihydrochloride) is a tyrosine analog, acts as a selective inhibitor of L-type amino acid transporter 1 (LAT1), and is used in cancer research.
In vitro	JPH203 (30 mM) induces mitochondria-dependent apoptosis in Saos2 human osteosarcoma cells. JPH203 (0.001-100 μM) inhibits 14C-leucine (1.0 μM) uptake slightly in FOB cells with an IC50 value of 92.12 ± 10.71 μM, but potently exihibts such effects in Saos2 cells with an IC50 value of 1.31 ± 0.27 μM. JPH203 (0.01 to 30 mM, 1-4 d) potently inhibits cell proliferation in Saos2 cells in a dose- and time-dependent manner, with an IC50 of 4.09-0.09 mM, but slightly inhibits that of FOB cells, with an IC50 of 24.1-2.8 mM.JPH203 Dihydrochloride is a selective inhibitor of LAT1. JPH203 inhibits 14C-leucine uptake in S2-hLAT1 and HT-29 cells, with IC50s of 0.14 μM and 0.06 μM. JPH203 (3-1000 μM) exhibits concentration-dependent inhibitory effects on S2-hLAT1 cell growth with an IC50 of 16.4 μM. JPH203 also displays inhibitory activities against HT-29 cell growth, with an IC50 value of 4.1 μM. JPH203 (0.001-100 μM) inhibits the 14C-leucine (1.0 μM) uptake in a concentration dependent way by the YD-38 cells with an IC50 value of 0.79 ± 0.06 μM. JPH203 slightly shows such effects in normal human oral keratinocytes (NHOKs). JPH203 (0.01-30 mM, 1-4 d) completely inhibits the proliferation of YD-38 cells in a dose- and time-dependent manner. However, JPH203 slightly inhibits the proliferation of NHOKs. JPH203 (30 mM) induces apoptosis of YD-38 cells. JPH203 (3 mM) also increases the level of cleaved PARP in activation of the caspases cascade.
In vivo	JPH203 exhibits dose-dependent inhibition on HT-29 tumor growth in nude mice.

Synonyms	KYT-0353 dihydrochloride
Molecular Weight	545.24
Formula	C23H21Cl4N3O4
CAS No.	1597402-27-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (91.70 mM), Sonification is recommended.

H2O: 10mg/mL (18.34mM)

References and Literature

1. Oda K, et al. L-type amino acid transporter 1 inhibitors inhibit tumor cell growth. Cancer Sci. 2010 Jan;101(1):173-9. 2. Yun DW, et al. JPH203, an L-type amino acid transporter 1-selective compound, induces apoptosis of YD-38 human oral cancer cells. J Pharmacol Sci. 2014;124(2):208-17. Epub 2014 Feb 4. 3. Choi DW, et al. JPH203, a selective L-type amino acid transporter 1 inhibitor,Choi DW, et al. JPH203, a selective L-type amino acid transporter 1 inhibitor, induces mitochondria-dependent apoptosis in Saos2 human osteosarcoma cells. Korean J Physiol Pharmacol. 2017 Nov;21(6):599-607.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Cancer Active Compound Library NO PAINS Compound Library Bioactive Compound Library Bioactive Compounds Library Max Anti-Cancer Compound Library

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Keywords

JPH203 dihydrochloride 1597402-27-1 Others JPH 203 JPH-203 KYT 0353 KYT-0353 Dihydrochloride JPH-203 Dihydrochloride JPH-203 dihydrochloride KYT-0353 JPH203 Dihydrochloride KYT0353 KYT0353 Dihydrochloride KYT-0353 dihydrochloride JPH 203 Dihydrochloride KYT 0353 Dihydrochloride JPH203 inhibitor inhibit

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