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JMV 2959

Catalog No. T11719L   CAS 925238-89-7

JMV 2959 is an antagonist of growth hormone secretagogue receptor type 1a (GHS-R1a) (IC50: 32 nM).

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JMV 2959 Chemical Structure
JMV 2959, CAS 925238-89-7
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Biological Description
Chemical Properties
Storage & Solubility Information
Description JMV 2959 is an antagonist of growth hormone secretagogue receptor type 1a (GHS-R1a) (IC50: 32 nM).
Targets&IC50 GHS-R1a:32 nM
In vitro JMV 2959 does not cause any intracellular calcium mobilization by itself[1].
In vivo JMV 2959 dose-dependently reduces the startle response (F(3.42)=4.4, p<0.01) and enhances prepulse inhibition (PPI) (F(3.42)=3.9, p<0.05) in the prepulse inhibition paradigm. JMV 2959 (6 mg/kg) causes a obviously suppression of locomotion on days 1 to 7 relative to baseline day 0 (F(7,49)=2.21, p<0.05). When administered alone, it does not increase food intake and does not obviously stimulate growth hormone (GH) release[1]. The alteration in the startle response is mainly due to a 27% decrease in the startle seen in the highest dose of JMV 2959 (6 mg/kg) compare to vehicle (p<0.05)[2]. Results also reveal a significant interaction between JMV 2959 treatment and day (F(1,14)=4.397, p<0.05)[3].
Molecular Weight 508.61
Formula C30H32N6O2
CAS No. 925238-89-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

TargetMolReferences and Literature

1. Moulin A, et al. The 1,2,4-triazole as a scaffold for the design of ghrelin receptor ligands: development of JMV 2959, a potent antagonist. Amino Acids. 2013 Feb;44(2):301-14. 2. Engel JA, et al. Blockade of growth hormone secretagogue receptor 1A signaling by JMV 2959 attenuates the NMDAR antagonist, phencyclidine-induced impairments in prepulse inhibition. Psychopharmacology (Berl). 2015 Dec;232(23):4285-92. 3. Clifford PS, et al. Attenuation of cocaine-induced locomotor sensitization in rats sustaining genetic or pharmacologic antagonism of ghrelin receptors. Addict Biol. 2012 Nov;17(6):956-63.

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Keywords

JMV 2959 925238-89-7 Others JMV-2959 JMV2959 inhibitor inhibit

 

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