Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Inolitazone (RS5444) a high-affinity PPARγ agonist. Inolitazone exhibits IC50 for growth inhibition is ~0.8 nM in vitro.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 113.00 | |
5 mg | In stock | $ 267.00 | |
10 mg | In stock | $ 427.00 | |
25 mg | In stock | $ 693.00 | |
50 mg | In stock | $ 987.00 | |
100 mg | In stock | $ 1,350.00 | |
500 mg | In stock | $ 2,690.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 338.00 |
Description | Inolitazone (RS5444) a high-affinity PPARγ agonist. Inolitazone exhibits IC50 for growth inhibition is ~0.8 nM in vitro. |
In vitro | Inolitazone (10 nM) inhibits the growth of DRO cells through a PPARγ-dependent mechanism[1]. Inolitazone upregulates the cell cycle kinase inhibitor, p21WAF1/CIP1. Inolitazone (10 nM) activates PPARγ:RXRα-dependent transcription utilizing a PPRE response element fused to a luciferase reporter gene (PPRE3-tk-luc). Inolitazone specifically activates PPARγ, but not PPARα or PPARδ. Inolitazone (10 nM) following transient transfection with the appropriate PPAR isoform (γ, α, or δ) and PPAR response element linked to a luciferase reporter in RIE rat small intestinal cell line, which does not express PPARs, yields increased luciferase activity only in the presence of PPARγ and PPRE3-tk-luc[2]. |
In vivo | In athymic nude mice prior to DRO tumor cell implantation, Inolitazone inhibits tumor growth in a dose responsive fashion. 0.025% Inolitazone inhibits growth on day 32 by 94.4%. In the 0.0025% treatment group, tumor growth is inhibited by 62.3% while the 0.00025% dose demonstrated no growth inhibitory activity as compared to control. Inolitazone treated animals demonstrate tumor growth inhibition of 68.9% in DRO tumors and 48.3% in ARO tumors on day 35. Inolitazone plus Paclitaxel demonstrate additive antiproliferative activity in cell culture and minimal ATC tumor growth[1]. |
Synonyms | RS5444, Efatutazone, CS-7017 |
Molecular Weight | 502.58 |
Formula | C27H26N4O4S |
CAS No. | 223132-37-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 55 mg/mL (109.43 mM)
You can also refer to dose conversion for different animals. More
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Inolitazone 223132-37-4 DNA Damage/DNA Repair Metabolism PPAR Peroxisome proliferator-activated receptors RS5444 RS 5444 Efatutazone RS-5444 CS 7017 CS-7017 Inhibitor inhibit CS7017 inhibitor