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Hellebrigenol

Catalog No. TN1729 CAS 508-79-2

Hellebrigenol shows cytotoxicity against HepG2 cells.

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Hellebrigenol, CAS 508-79-2

Pack Size	Availability	Price/USD	Quantity
5 mg	In stock	$ 1,158.00
1 mL * 10 mM (in DMSO)	In stock	$ 1,389.00

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Biological Description

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Description

Hellebrigenol shows cytotoxicity against HepG2 cells.

In vitro

A total of 39 metabolites from 10 bufadienolides were detected and identified by ultrahigh-performance liquid chromatography (UHPLC) coupled with an LTQ Orbitrap mass spectrometer. The results showed that hydroxylation and dehydrogenation were the major metabolic pathways of bufadienolides in human liver microsomes (HLMs). CYP3A4 was found to be the major metabolic enzyme and CYP2D6 only mediated the dehydrogenation reaction. A systematic validated cytotoxicity evaluation method for bufadienolide metabolites at equal equivalents was established. Hellebrigenin (1), Hellebrigenol (2), arenobufagin (3), bufotalin (5), and bufalin (6) were selected to determine their cytotoxicity against HepG2 cells before and after incubation in HLMs. All the test samples were enriched by a validated solid-phase extraction (SPE) method.

Molecular Weight	418.52
Formula	C24H34O6
CAS No.	508-79-2

Storage

store at low temperature,keep away from direct sunlight

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Metabolites profiling of 10 bufadienolides in human liver microsomes and their cytotoxicity variation in HepG2 cell.Anal Bioanal Chem. 2016 Apr;408(10):2485-95.

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Keywords

Hellebrigenol 508-79-2 Others inhibitor inhibit

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