Powder: -20°C for 3 years | In solvent: -80°C for 1 year
HC-067047 hydrochloride is a potent and selective TRPV4 antagonist. HC-067047 hydrochloride reversibly inhibited currents through the human, rat, and mouse TRPV4 orthologs with IC50 values of 486 nM, 133nM, and 17 nM, respectively.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 133.00 | |
5 mg | In stock | $ 302.00 | |
10 mg | In stock | $ 453.00 | |
25 mg | In stock | $ 747.00 | |
50 mg | In stock | $ 1,050.00 | |
100 mg | In stock | $ 1,420.00 | |
500 mg | In stock | $ 2,830.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 381.00 |
Description | HC-067047 hydrochloride is a potent and selective TRPV4 antagonist. HC-067047 hydrochloride reversibly inhibited currents through the human, rat, and mouse TRPV4 orthologs with IC50 values of 486 nM, 133nM, and 17 nM, respectively. |
In vitro | TRPV4 is a hyperglycemia-related factor that can inhibit cell proliferation and promote cell apoptosis by activating the MAPK signaling pathway in HEI-OC1 cells[1]. |
In vivo | HC-067047 increases functional bladder capacity and reduces micturition frequency in mice and rats with cystitis[2]. |
Molecular Weight | 507.98 |
Formula | C26H29ClF3N3O2 |
CAS No. | 1481646-76-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 55 mg/mL (108.27 mM)
You can also refer to dose conversion for different animals. More
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HC067047 Hydrochloride(883031-03-6 free base) 1481646-76-7 Membrane transporter/Ion channel TRP/TRPV Channel HC067047 Hydrochloride(883031 03 6 free base) HC-067047 Hydrochloride(883031-03-6 free base) HC067047 Hydrochloride(883031036 free base) inhibitor inhibit