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Gut restricted-7

Catalog No. T11515 CAS 2553218-46-3

Synonyms: GR-7

Gut restricted-7 (GR-7) (GR-7) is a covalent and orally active pan-bile salt hydrolase (BSH) inhibitor. It decreases gut bacterial BSHs and decreases deconjugated bile acid levels in the feces of mice.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Gut restricted-7, CAS 2553218-46-3

Pack Size	Availability	Price/USD
1 mg	In stock	$ 157.00
5 mg	In stock	$ 332.00
10 mg	In stock	$ 532.00
25 mg	In stock	$ 863.00
50 mg	In stock	$ 1,190.00
1 mL * 10 mM (in DMSO)	In stock	$ 373.00

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Purity: 99.27%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Gut restricted-7 (GR-7) (GR-7) is a covalent and orally active pan-bile salt hydrolase (BSH) inhibitor. It decreases gut bacterial BSHs and decreases deconjugated bile acid levels in the feces of mice.
In vitro	Gut restricted-7 (60 μM) does not affect the epithelial barrier integrity of Caco-2 cells, suggesting that this compound is relatively nontoxic. Gut restricted-7 also does not affect microbial biomass.
In vivo	The C57BL/6 mice fed with either powdered chow containing 0.09% Gut restricted-7 (w/w) for 1 d day or powdered chow alone.Gut restricted-7 significant inhibits the BSH activity in the feces of inhibitor-treated mice 8 h post-diet change.20picomol/mg wet mass (~20 μM) of Gut restricted-7 in cecal contents is detected.

Synonyms	GR-7
Molecular Weight	495.64
Formula	C25H41FNaO5S
CAS No.	2553218-46-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 250 mg/mL (489.59 mM), Sonication is recommended.

References and Literature

1. Adhikari AA, et al. Development of a covalent inhibitor of gut bacterial bile salt hydrolases. Nat Chem Biol. 2020 Mar;16(3):318-326.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Infection Compound Library Bioactive Compound Library Anti-Cancer Compound Library Bioactive Compounds Library Max Ion Channel Inhibitor Library NO PAINS Compound Library Anti-Bacterial Compound Library Orally Active Compound Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Gut restricted-7 2553218-46-3 Membrane transporter/Ion channel Potassium Channel acid Inhibitor GR-7 bile Bacterial orally Nontoxic Gut restricted 7 GR7 Gut restricted7 gut BSH gut-restricted inhibit GR 7 inhibitor

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