Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Guanoxabenz is an α2 adrenergic receptor agonist.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 6-8 weeks | $ 1,520.00 | |
50 mg | 6-8 weeks | $ 1,980.00 | |
100 mg | 6-8 weeks | $ 2,500.00 |
Description | Guanoxabenz is an α2 adrenergic receptor agonist. |
In vitro | The formation of high-affinity Guanoxabenz binding is inhibited in both a time- and concentration-dependent manner through preincubation with the LW03 N-hydroxyguanidine analogue of Guanoxabenz, as well as by various metabolic inhibitors such as allopurinol, 1-chloro-2,4-dinitrobenzene, 5,5'-dithiobis-(2-nitrobenzoic acid), cibacron blue, phenyl-p-benzoquinone, didox, and trimidox. Additionally, the spleen cytosolic fraction facilitates the reduction of Guanoxabenz to guanabenz, with the latter exhibiting an almost 100-fold higher affinity for rat alpha2A-adrenoceptors than Guanoxabenz itself. This suggests a complex interaction between Guanoxabenz, its analogues, and metabolic inhibitors in relation to their binding affinities and reduction processes. |
In vivo | High affinity Guanoxabenz binding is also induced in rat brain membranes after addition of NADH or NADPH cofactors. The rat cerebral cortex contains an enzymatic activity that may activate Guanoxabenz leading to formation of a metabolite showing high affinity for alpha 2-adrenoceptors.Guanoxabenz and guanabenz are both known as centrally active antihypertensive drugs.?enzymatic activity in the rat spleen can induce N-reduction of Guanoxabenz, leading to high affinity alphaα2 adrenergic receptor binding, due to the formation of theα2 adrenergic receptor active drug, guanabenz. |
Synonyms | Hydroxyguanabenz |
Molecular Weight | 247.08 |
Formula | C8H8Cl2N4O |
CAS No. | 24047-25-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
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Guanoxabenz 24047-25-4 Others Hydroxyguanabenz inhibitor inhibit