Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Golidocitinib (AZD4205) is a selective JAK1 inhibitor (IC50: 73 nM) and weakly inhibits JAK2/JAK3 (IC50: <14.7, <30 μM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | In stock | $ 97.00 | |
5 mg | In stock | $ 166.00 | |
10 mg | In stock | $ 282.00 | |
25 mg | In stock | $ 489.00 | |
50 mg | In stock | $ 651.00 | |
100 mg | In stock | $ 927.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 178.00 |
Description | Golidocitinib (AZD4205) is a selective JAK1 inhibitor (IC50: 73 nM) and weakly inhibits JAK2/JAK3 (IC50: >14.7, >30 μM). |
Targets&IC50 | JAK1:73 nM |
In vitro | AZD4205 significantly inhibits STAT3 phosphorylation in NCI-H 1975 cells (IC50: 161 nM). |
In vivo | AZD4205, administered orally at doses of 12.5 mg/kg, 25 mg/kg, or 50 mg/kg twice daily (BID), exhibits dose-dependent antitumor effects when used alone. Additionally, it boosts the antitumor efficacy of osimertinib when compared to the administration of osimertinib alone in mice implanted with NCI-H1975 cells. |
Synonyms | AZD4205 |
Molecular Weight | 489.57 |
Formula | C25H31N9O2 |
CAS No. | 2091134-68-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 250 mg/mL (510.65 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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Golidocitinib 2091134-68-6 Angiogenesis Chromatin/Epigenetic JAK/STAT signaling Stem Cells JAK AZD-4205 Janus kinase AZD 4205 Inhibitor inhibit AZD4205 inhibitor