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Home > Angiogenesis > FLT > Gandotinib

Gandotinib

Catalog No. T2638    CAS 1229236-86-5    Synonyms: LY2784544

LY2784544(Gandotinib) is a potent JAK2 inhibitor (IC50: 3 nM), effective in JAK2V617F(Ki: 0.245 nM). The selectivity is higher 8- and 20-fold than JAK1 and JAK3.

Pack Size Availability Price/USD Quantity
2 mg In stock 75.00
5 mg In stock 132.00
10 mg In stock 186.00
25 mg In stock 461.00
50 mg In stock 700.00
100 mg In stock 956.00
1 mL * 10 mM (in DMSO) In stock 136.00
Bulk Size: Please Quote for Discount Please Quote for Bulk Size
Biological Activity:

Product Description:

LY2784544(Gandotinib) is a potent JAK2 inhibitor (IC50: 3 nM), effective in JAK2V617F(Ki: 0.245 nM). The selectivity is higher 8- and 20-fold than JAK1 and JAK3.

Receptor:

FLT3; JAK1; JAK2; JAK2 (V617F);

Chemical Information:
Molecular Weight 469.94
Formula C23H25ClFN7O
CAS Number 1229236-86-5
Solubility

DMSO: 87 mg/mL (185.1 mM)

Ethanol: 9 mg/mL (19.15 mM)

Water: <1 mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )
Storage store at -80°C
Remark For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ℃ for several month.