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GSK-843

Catalog No. T11474 CAS 1601496-05-2

Synonyms: GSK'843

GSK-843 (GSK'843) is a selective and potent RIP3 inhibitor with an IC50 value of 8.6 nM for the structural domain of RIP3 kinase.GSK-843 has potential analgesic activity, inhibits the expression of RIP3 and NLRP3 in the SDH of CFA mice, and can be used as an adjunctive therapy for the treatment of inflammation.

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GSK-843, CAS 1601496-05-2

Pack Size	Availability	Price/USD	Quantity
2 mg	In stock	$ 223.00
1 mL * 10 mM (in DMSO)	In stock	$ 302.00

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Purity: 99.18%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	GSK-843 (GSK'843) is a selective and potent RIP3 inhibitor with an IC50 value of 8.6 nM for the structural domain of RIP3 kinase.GSK-843 has potential analgesic activity, inhibits the expression of RIP3 and NLRP3 in the SDH of CFA mice, and can be used as an adjunctive therapy for the treatment of inflammation.
Targets&IC50	RIP3:6.5 nM, RIP3:8.6 nM
In vitro	RIP3i GSK-843 and GSK-872 by screening conventional small molecule libraries. These compounds bound RIP3 kinase domain with high affinity (IC50 = 8.6 nM and 1.8 nM, respectively,and inhibited kinase activity (IC50 = 6.5 nM and 1.3 nM, respectively[1].

Synonyms	GSK'843
Molecular Weight	377.49
Formula	C19H15N5S2
CAS No.	1601496-05-2

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 30 mg/mL (79.47 mM), Sonification is recommended.

References and Literature

1. Mandal P, et al. RIP3 induces apoptosis independent of pronecrotic kinase activity. Mol Cell. 2014 Nov 20;56(4):481-95. 2. Kaiser WJ, et al. Toll-like receptor 3-mediated necrosis via TRIF, RIP3, and MLKL. J Biol Chem. 2013 Oct 25;288(43):31268-79.

Related Products

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RIPK1-IN-17 Necrostatin-1 RIPK2/3-IN-1 HTH-01-091 RIPK1-IN-7 PK68 RI-962 Necrostatin-34

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Keywords

GSK-843 1601496-05-2 Apoptosis NF-Κb RIP kinase GSK843 GSK'843 GSK 843 inhibitor inhibit

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