Powder: -20°C for 3 years | In solvent: -80°C for 1 year
GSK 525768A, the inactive enantiomer of GSK525762A, exhibits no activity towards BET.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | 6-8 weeks | $ 198.00 | |
5 mg | 6-8 weeks | $ 347.00 | |
25 mg | 6-8 weeks | $ 1,170.00 | |
50 mg | 6-8 weeks | $ 1,530.00 | |
100 mg | 6-8 weeks | $ 1,990.00 | |
1 mL * 10 mM (in DMSO) | 6-8 weeks | $ 382.00 |
Description | GSK 525768A, the inactive enantiomer of GSK525762A, exhibits no activity towards BET. |
In vitro | GSK 525768A interacts with the protein's module by establishing hydrogen bonds with the conserved asparagine residue, effectively mimicking the acetylated lysine's binding mechanism. This interaction leads to the compound's binding deeper within the acetylated lysine's binding site, all the while preserving the position of conserved water molecules in the acetyl-lysine binding cavity's base. GSK 525768A exhibits no activity towards BET and is identified as the (R)-enantiomer of GSK525762A. Contrasting its counterpart, GSK525762A, which influences the regulation of apolipoprotein A1 (APOA1) levels in liver cell assays, GSK 525768A does not impact APOA1 release, highlighting a distinctive functional divergence between the two enantiomers. |
Molecular Weight | 423.9 |
Formula | C22H22ClN5O2 |
CAS No. | 1260530-25-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (235.90 mM)
You can also refer to dose conversion for different animals. More
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GSK 525768A 1260530-25-3 Others inhibitor inhibit