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GS-441524

Catalog No. T7222 CAS 1191237-69-0

Synonyms: GS 441524 triphosphate

GS-441524 treatment of cats with naturally occurring feline infectious peritonitis.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

GS-441524, CAS 1191237-69-0

Pack Size	Availability	Price/USD
50 mg	In stock	$ 50.00
100 mg	In stock	$ 68.00
1 mL * 10 mM (in DMSO)	In stock	$ 24.00

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Purity: 99.9%

Purity: 99.75%

Purity: 99.73%

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Chemical Properties

Storage & Solubility Information

Description	GS-441524 treatment of cats with naturally occurring feline infectious peritonitis.
Targets&IC50	FIPV:0.78 μM (EC50)
In vivo	Four of the 31 cats that presented with severe disease died or were euthanized within 2-5 days and a fifth cat after 26 days. The 26 remaining cats completed the planned 12 weeks or more of treatment(GS-441524). Eighteen of these 26 cats remain healthy at the time of publication after one round of treatment, while eight others suffered disease relapses within 3-84 days. Six of the relapses were non-neurological and two neurological. Three of the eight relapsing cats were treated again at the same dosage, while five cats had the dosage increased from 2.0 to 4.0 mg/kg q24h. The five cats treated a second time at the higher dosage, including one with neurological disease, responded well and also remain healthy . However, one of the three cats re-treated at the original lower dosage relapsed with neurological disease and was euthanized, while the two remaining cats responded favorably but relapsed a second time. These two cats were successfully treated a third time at the higher dosage, producing 25 long-time survivors. One of the 25 successfully treated cats was subsequently euthanized due to presumably unrelated heart disease, while 24 remain healthy[1].
Animal Research	Cats ranged from 3.4-73 months of age (mean 13.6 months); 26 had effusive or dry-to-effusive FIP and five had non-effusive disease. Cats with severe neurological and ocular FIP were not recruited. The group was started on GS-441524 at a dosage of 2.0 mg/kg SC q24h for at least 12 weeks and increased when indicated to 4.0 mg/kg SC q24h[1].

Synonyms	GS 441524 triphosphate
Molecular Weight	291.26
Formula	C12H13N5O4
CAS No.	1191237-69-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (171.66 mM)

References and Literature

1. Pedersen N C , Perron M , Bannasch M , et al. Efficacy and safety of the nucleoside analog GS-441524 for treatment of cats with naturally occurring feline infectious peritonitis[J]. Journal of Feline Medicine & Surgery, 2019. 2. Murphy B G , Perron M , Murakami E , et al. The nucleoside analog GS-441524 strongly inhibits feline infectious peritonitis (FIP) virus in tissue culture and experimental cat infection studies[J]. Veterinary Microbiology, 2018, 219:226-233. 3. Xu L, Tan B, Huang D, et al. Remdesivir inhibits renal fibrosis in obstructed kidneys[J]. bioRxiv. 2020. 4. Wang Q, Wu J, Wang H, et al. Structural basis for RNA replication by the SARS-CoV-2 polymerase[J]. Cell. 2020.

Citations

1. Wang Q, Wu J, Wang H, et al. Structural basis for RNA replication by the SARS-CoV-2 polymerase. Cell. 2020, 182(2): 417-428. e13. 2. Bennett R P, Postnikova E N, Eaton B P, et al. Sangivamycin is highly effective against SARS-CoV-2 in vitro and has favorable drug properties. JCI insight. 2022, 7(1). 3. Xu L, Tan B, Huang D, et al. Remdesivir inhibits renal fibrosis in obstructed kidneys. Frontiers in Pharmacology. 2021, 12: 1668 4. Xu L, Tan B, Huang D, et al. Remdesivir Inhibits Tubulointerstitial Fibrosis in Obstructed Kidneys. Frontiers in Pharmacology. 2021, 12: 1668. 5. Mohseni N, Royster A, Ren S, et al.A novel compound targets the feline infectious peritonitis virus nucleocapsid protein and inhibits viral replication in cell culture.Journal of Biological Chemistry.2023: 102976.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Clinical Compound Library Anti-Cancer Drug Library Drug Repurposing Compound Library Anti-Viral Compound Library Bioactive Compounds Library Max Cell Cycle Compound Library ReFRAME Related Library Anti-Aging Compound Library DNA Damage & Repair Compound Library Anti-Cancer Compound Library

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Keywords

GS-441524 1191237-69-0 Cell Cycle/Checkpoint DNA Damage/DNA Repair Microbiology/Virology Others SARS-CoV DNA/RNA Synthesis Inhibitor feline SARS coronavirus virus GS-441524 Triphosphate GS441524 FIPV infectious peritonitis inhibit GS 441524 Triphosphate GS 441524 triphosphate GS 441524 GS441524 Triphosphate inhibitor

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