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GNF-PF-3777

Catalog No. T10199 CAS 77603-42-0

Synonyms: 8-Nitrotryptanthrin

GNF-PF-3777 (8-Nitrotryptanthrin) (8-Nitrotryptanthrin) is a potent inhibitor of human indoleamine 2,3-dioxygenase 2 (hIDO2; Ki: 0.97 μM).

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GNF-PF-3777, CAS 77603-42-0

Pack Size	Availability	Price/USD
1 mg	In stock	$ 77.00
5 mg	In stock	$ 207.00
10 mg	In stock	$ 312.00
25 mg	In stock	$ 526.00
50 mg	In stock	$ 759.00
100 mg	In stock	$ 1,070.00
500 mg	In stock	$ 2,130.00
1 mL * 10 mM (in DMSO)	In stock	$ 187.00

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Purity: 99.47%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	GNF-PF-3777 (8-Nitrotryptanthrin) (8-Nitrotryptanthrin) is a potent inhibitor of human indoleamine 2,3-dioxygenase 2 (hIDO2; Ki: 0.97 μM).
Targets&IC50	IDO2 (recombinant human):0.97 μM (ki), IDO2 (recombinant human):1.8 μM
In vitro	GNF-PF-3777 (Compound 5i) is a potent hIDO2 inhibitor with superior efficiency far better than that of the most frequently-used inhibitor L-1-MT. GNF-PF-3777 demonstrates much stronger inhibition (1.87 μM) than both L-1-MT (82.53 μM) and D-1-MT (262.75 μM). GNF-PF-3777 exhibits significant antitrypanosomal activity (EC50: 0.82 μM) [2]. GNF-PF-3777 has a microplate Alamar Blue assay (MABA) minimum inhibitory concentration (MIC) value of 0.032 μg/mL. GNF-PF-3777 also has a LORA MIC value of 2.4 μg/mL, while the majority of analogs lack LORA activity [3].

Synonyms	8-Nitrotryptanthrin
Molecular Weight	293.23
Formula	C15H7N3O4
CAS No.	77603-42-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 6.4 mg/mL (21.83 mM), Sonication is recommended.

References and Literature

1. Li J, et al. Establishment of a human indoleamine 2, 3-dioxygenase 2 (hIDO2) bioassay system and discovery of tryptanthrin derivatives as potent hIDO2 inhibitors. Eur J Med Chem. 2016 Nov 10;123:171-9. 2. Scovill J, et al. Antitrypanosomal activities of tryptanthrins. Antimicrob Agents Chemother. 2002 Mar;46(3):882-3. 3. Hwang JM, et al. Design, synthesis, and structure-activity relationship studies of tryptanthrins as antitubercular agents. J Nat Prod. 2013 Mar 22;76(3):354-67.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Immuno-Oncology Compound Library Metabolism Compound Library NO PAINS Compound Library Bioactive Compound Library Anti-Cancer Metabolism Compound Library Bioactive Compounds Library Max

Related Products

Related compounds with same targets

IDO1-IN-1 IDO-IN-8 IDO-IN-9 PF-06840003 IDO1-IN-5 IDO-IN-3 IDO-IN-11 IDO5L

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

GNF-PF-3777 77603-42-0 Metabolism IDO Indoleamine 2,3-Dioxygenase (IDO) GNFPF3777 GNF-PF 3777 GNF PF 3777 Inhibitor 8-Nitrotryptanthrin inhibit GNF-PF3777 inhibitor

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