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GLP-1(7-36), amide

Catalog No. T3984 CAS 107444-51-9

Synonyms: MKC 253, Human GLP-1-(7-36)-amide, Glucagon-like Peptide 1 (7-36) amide, Glucagon-Like Peptide (GLP) I (7-36), amide, human, GLP-1(7-36), GLP-1-(7-36)-amide

GLP-1(7-36), amide (MKC 253) is a peptide hormone released from intestinal L-cells upon nutrient consumption. It binds the GLP-1 receptor in the pancreas and displays various antidiabetic effects by potentiating glucose-induced secretion of insulin from pancreatic β-cells, increasing insulin expression.

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GLP-1(7-36), amide, CAS 107444-51-9

Pack Size	Availability	Price/USD
1 mg	Inquiry	$ 185.00
2 mg	Inquiry	$ 327.00
5 mg	Inquiry	$ 552.00
10 mg	Inquiry	$ 793.00
25 mg	Inquiry	$ 1,220.00
50 mg	Inquiry	$ 1,630.00
100 mg	Inquiry	$ 2,220.00

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Purity: 99.85%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	GLP-1(7-36), amide (MKC 253) is a peptide hormone released from intestinal L-cells upon nutrient consumption. It binds the GLP-1 receptor in the pancreas and displays various antidiabetic effects by potentiating glucose-induced secretion of insulin from pancreatic β-cells, increasing insulin expression.
In vitro	GLP-1 secretion by human enteroendocrine NCI-H716 cells is augmented in a dose-dependent manner by the addition of CPE.
In vivo	GLP-1 secretion is compatible with the increase in observed active GLP-1(7-36) amide levels in the portal blood after administration with CPE alone in mice.

Synonyms	MKC 253, Human GLP-1-(7-36)-amide, Glucagon-like Peptide 1 (7-36) amide, Glucagon-Like Peptide (GLP) I (7-36), amide, human, GLP-1(7-36), GLP-1-(7-36)-amide
Molecular Weight	3297.63
Formula	C149H226N40O45
CAS No.	107444-51-9

Storage

keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 10 mM

References and Literature

1. Fujii Y et al. Ingestion of coffee polyphenols increases postprandial release of the active glucagon-like peptide-1(GLP-1(7-36)) amide in C57BL/6J mice. J Nutr Sci. 2015 Mar 3 2. Perry et al (2002) Protection and reversal of excitotoxic neuronal damage by glucagon-like peptide-1 and exendin-4. J.Pharmacol.Exp.Ther. 302 881. 3. Perfetti R., et al. Glucagon-like peptide-1: a major regulator of pancreatic β-cell function. Eur.J.Endocrinol. 143 717.

Citations

1. Yan Y, Niu Z, Sun C, et al. Hepatic thyroid hormone signalling modulates glucose homeostasis through the regulation of GLP-1 production via bile acid-mediated FXR antagonism. Nature Communications. 2022, 13(1): 1-16.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Diabetic Compound Library Peptide Compound Library Clinical Compound Library GPCR Compound Library NO PAINS Compound Library Anti-Metabolism Disease Compound Library Bioactive Compounds Library Max Bioactive Compound Library

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Keywords

GLP-1(7-36), amide 107444-51-9 GPCR/G Protein Glucagon Receptor MKC-253 MKC253 GCGR inhibit MKC 253 GLP 1(7 36), amide Glucagon-like Peptide 1 Amide Human GLP-1-(7-36)-amide GLP-1 GLP-1-amide Glucagon-like Peptide 1 GLP1(736), amide GLP 1 Glucagon-like Peptide 1 (7-36) amide Inhibitor Glucagon-Like Peptide (GLP) I (7-36), amide, human GLP1 GLP-1(7-36) Human GLP-1-amide GLP-1-(7-36)-amide Glucagon-Like Peptide (GLP) I , amide, human GLP-1, Amide inhibitor

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