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Flosulide

Catalog No. T11296 CAS 80937-31-1

Synonyms: ZK 38997, CGP 28238

Flosulide is an effective selective COX-2 inhibitor for the treatment of inflammatory diseases.

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Flosulide, CAS 80937-31-1

Pack Size	Availability	Price/USD
25 mg	6-8 weeks	$ 1,670.00
50 mg	6-8 weeks	$ 2,180.00
100 mg	6-8 weeks	$ 2,800.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

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Description	Flosulide is an effective selective COX-2 inhibitor for the treatment of inflammatory diseases.
In vitro	Flosulide entirely inhibits the mitotic activity of OSC-2 cells while having no impact on the mitotic activity of OSC-1 cells. Additionally, Flosulide demonstrates a concentration-dependent effect on the OSC-2 cell line by fully suppressing PGE2 production across a range of 1 nM to 100 μM; however, it does not affect prostaglandin (PG) synthesis in OSC-1 cells.
In vivo	In normovolemic rats, flosulide enhances renal plasma flow (RPF) and glomerular filtration rate (GFR), while in hypovolemic rats, it reduces these measures at dosages between 5-25 mg/kg. At a dosage of 5 mg/kg, flosulide lowers 6-keto-PGF1alpha, and at 25 mg/kg or following 10 mg/kg of indomethacin, it leads to a decrease in both 6-keto-PGF1alpha and TXB2[1]. Furthermore, flosulide at 0.75 mg/day notably decreases proteinuria compared to aspirin treatment and results in significantly higher plasma protein and albumin levels than those observed in aspirin-treated rats[3].

Synonyms	ZK 38997, CGP 28238
Molecular Weight	353.34
Formula	C16H13F2NO4S
CAS No.	80937-31-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Turull A, et al. Acute effects of the anti-inflammatory cyclooxygenase-2 selective inhibitor, flosulide, on renal plasma flow and glomerular filtration rate in rats. Inflammation. 2001 Apr;25(2):119-28. 2. Zimmermann KC, et al. Cyclooxygenase-2 expression in human esophageal carcinoma. Cancer Res. 1999 Jan 1;59(1):198-204. 3. Heise G, et al. Different actions of the cyclooxygenase 2 selective inhibitor flosulide in rats with passive Heymann nephritis. Nephron. 1998 Oct;80(2):220-6.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Flosulide 80937-31-1 Immunology/Inflammation Neuroscience COX ZK-38997 ZK38997 CGP-28238 ZK 38997 CGP 28238 CGP28238 inhibitor inhibit

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