-20℃ 3 years powder
-80℃ 2 years in solvent
Favipiravir (T-705), an effective and selective RNA-dependent RNA polymerase inhibitor, are applied to treat influenza virus infections.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | In stock | 31.00 | |
5 mg | In stock | 50.00 | |
10 mg | In stock | 68.00 | |
25 mg | In stock | 82.00 | |
50 mg | In stock | 95.00 | |
100 mg | In stock | 140.00 | |
1 mL * 10 mM (in DMSO) | In stock | 54.00 |
Description | Favipiravir (T-705), an effective and selective RNA-dependent RNA polymerase inhibitor, are applied to treat influenza virus infections. |
Targets&IC50 | RNA-dependent RNA polymerase, |
In vivo | In influenza virus-infected mice, Favipiravir (200 mg/kg/day, p.o.) protects the mice from death from influenza virus infection. [1] In mice experimentally infected with Ebola virus, Favipiravir efficiently blocks viral production, reaching an antiviral effectiveness of 95% and 99.6% at 2 and 6days after initiation of treatment, respectively. [3] |
Cell Research |
The cytotoxicity of T-705 is evaluated by an assay with XTT. XTT is converted to aqueous formazan by an enzyme in MDCK cells, Vero cells, HEL cells, A549 cells, HeLa cells, and HEp-2 cells. The compounds are diluted to the appropriate concentrations (volume, 100 μl) with test medium (EMEM containing 10% FCS) in 96-well culture plates in which each well contains a concentration of 2 × 103 cells/100 μL. The test plates are incubated for 3 days at 37°C in 100% humidity and 5% CO2. After 3 days, 50 μl of the XTT reagent (1 mg/ml in FCS-free EMEM containing 5 mM phenazine methosulfate) is added, and the reaction product is assayed by measurement of the absorbance at 450 nm with a microplate reader. Cytotoxicity is expressed as the 50% cell-inhibitory concentration (CC50).(Only for Reference)
Cell lines: MDCK cells, Vero cells, HEL cells, A549 cells, HeLa cells, and HEp-2 cells
|
Animal Research |
Animal Model: Mice infected with influenza virus A/PR/8/34
|
Synonyms | 6-Fluoro-3-oxo-3,4-dihydropyrazine-2-carboxamide, T-705, favilavir |
Purity | 100.00% |
Appearance | solid |
Molecular Weight | 157.10 |
Formula | C5H4FN3O2 |
CAS No. | 259793-96-9 |
-20℃ 3 years powder
-80℃ 2 years in solvent
DMSO: 29 mg/mL (184.6 mM)
Ethanol: 12 mg/mL (76.4 mM)
Water: 5 mg/mL (31.82 mM), warmed
( < 1 mg/ml refers to the product slightly soluble or insoluble )
Safe and effective drug dosing is necessary, regardless of its purpose of administration. Learn More
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Answers to questions you may have can be found in the Inhibitor Handling Instructions. Topics include how to prepare stock solutions, how to store Products, and issues that need special attention for cell-based assays and animal experiments.