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Favipiravir

Catalog No. T6833   CAS 259793-96-9
Synonyms: 6-Fluoro-3-oxo-3,4-dihydropyrazine-2-carboxamide, T-705, favilavir
Purity 100.00% Datasheet

Favipiravir (T-705), an effective and selective RNA-dependent RNA polymerase inhibitor, are applied to treat influenza virus infections.

Favipiravir, CAS 259793-96-9
Pack Size Availability Price/USD Quantity
2 mg In stock 31.00
5 mg In stock 50.00
10 mg In stock 68.00
25 mg In stock 82.00
50 mg In stock 95.00
100 mg In stock 140.00
1 mL * 10 mM (in DMSO) In stock 54.00
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Purity 100.00%
Biological Description
Chemical Properties
Storage & Solubility Information
Description Favipiravir (T-705), an effective and selective RNA-dependent RNA polymerase inhibitor, are applied to treat influenza virus infections.
Targets&IC50 RNA-dependent RNA polymerase,  
In vivo In influenza virus-infected mice, Favipiravir (200 mg/kg/day, p.o.) protects the mice from death from influenza virus infection. [1] In mice experimentally infected with Ebola virus, Favipiravir efficiently blocks viral production, reaching an antiviral effectiveness of 95% and 99.6% at 2 and 6days after initiation of treatment, respectively. [3]
Cell Research
The cytotoxicity of T-705 is evaluated by an assay with XTT. XTT is converted to aqueous formazan by an enzyme in MDCK cells, Vero cells, HEL cells, A549 cells, HeLa cells, and HEp-2 cells. The compounds are diluted to the appropriate concentrations (volume, 100 μl) with test medium (EMEM containing 10% FCS) in 96-well culture plates in which each well contains a concentration of 2 × 103 cells/100 μL. The test plates are incubated for 3 days at 37°C in 100% humidity and 5% CO2. After 3 days, 50 μl of the XTT reagent (1 mg/ml in FCS-free EMEM containing 5 mM phenazine methosulfate) is added, and the reaction product is assayed by measurement of the absorbance at 450 nm with a microplate reader. Cytotoxicity is expressed as the 50% cell-inhibitory concentration (CC50).(Only for Reference)
Cell lines: MDCK cells, Vero cells, HEL cells, A549 cells, HeLa cells, and HEp-2 cells
Animal Research
Animal Model: Mice infected with influenza virus A/PR/8/34
Synonyms 6-Fluoro-3-oxo-3,4-dihydropyrazine-2-carboxamide, T-705, favilavir
Purity 100.00%
Appearance solid
Molecular Weight 157.10
Formula C5H4FN3O2
CAS No. 259793-96-9

Storage

-20℃ 3 years powder

-80℃ 2 years in solvent

Solubility Information

DMSO: 29 mg/mL (184.6 mM)

Ethanol: 12 mg/mL (76.4 mM)

Water: 5 mg/mL (31.82 mM), warmed

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Furuta Y, et al. Antimicrob Agents Chemother. 2002, 46(4), 977-981. 2. Baranovich T, et al. J Virol. 2013, 87(7), 3741-3751. 3. Madelain V, et al. Antiviral Res. 2015, 123, 70-77.

Related Compound Libraries

This product is contained In the following compound libraries:
Approved Drug Library Bioactive Compound Library Inhibitor Library Anti-infection Compound Library Fluorochemical Library

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Ferrous fumarate Sodium Nitroprusside Methylene Blue trihydrate Mercaptopurine Phenethyl alcohol Mecarbinate cis-Anethol Mephenesin

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Answers to questions you may have can be found in the Inhibitor Handling Instructions. Topics include how to prepare stock solutions, how to store Products, and issues that need special attention for cell-based assays and animal experiments.