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Favipiravir

Catalog No. T6833 CAS 259793-96-9

Synonyms: 6-Fluoro-3-oxo-3,4-dihydropyrazine-2-carboxamide, T-705, favilavir

Purity 100.00% Datasheet

Favipiravir (T-705), an effective and selective RNA-dependent RNA polymerase inhibitor, are applied to treat influenza virus infections.

Favipiravir, CAS 259793-96-9

Pack Size	Availability	Price/USD
2 mg	In stock	31.00
5 mg	In stock	50.00
10 mg	In stock	68.00
25 mg	In stock	82.00
50 mg	In stock	95.00
100 mg	In stock	140.00
1 mL * 10 mM (in DMSO)	In stock	54.00

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Purity 98.16%

HNMR HPLC COA Datasheet

Purity 100.00%

HNMR HPLC COA Datasheet

Purity 100.00%

HNMR HPLC Datasheet

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Favipiravir (T-705), an effective and selective RNA-dependent RNA polymerase inhibitor, are applied to treat influenza virus infections.
Targets&IC50	RNA-dependent RNA polymerase,
In vivo	In influenza virus-infected mice, Favipiravir (200 mg/kg/day, p.o.) protects the mice from death from influenza virus infection. [1] In mice experimentally infected with Ebola virus, Favipiravir efficiently blocks viral production, reaching an antiviral effectiveness of 95% and 99.6% at 2 and 6days after initiation of treatment, respectively. [3]
Cell Research	The cytotoxicity of T-705 is evaluated by an assay with XTT. XTT is converted to aqueous formazan by an enzyme in MDCK cells, Vero cells, HEL cells, A549 cells, HeLa cells, and HEp-2 cells. The compounds are diluted to the appropriate concentrations (volume, 100 μl) with test medium (EMEM containing 10% FCS) in 96-well culture plates in which each well contains a concentration of 2 × 103 cells/100 μL. The test plates are incubated for 3 days at 37°C in 100% humidity and 5% CO2. After 3 days, 50 μl of the XTT reagent (1 mg/ml in FCS-free EMEM containing 5 mM phenazine methosulfate) is added, and the reaction product is assayed by measurement of the absorbance at 450 nm with a microplate reader. Cytotoxicity is expressed as the 50% cell-inhibitory concentration (CC50).(Only for Reference) Cell lines: MDCK cells, Vero cells, HEL cells, A549 cells, HeLa cells, and HEp-2 cells
Animal Research	Animal Model: Mice infected with influenza virus A/PR/8/34

Synonyms	6-Fluoro-3-oxo-3,4-dihydropyrazine-2-carboxamide, T-705, favilavir
Purity	100.00%
Appearance	solid
Molecular Weight	157.10
Formula	C5H4FN3O2
CAS No.	259793-96-9

Storage

-20℃ 3 years powder

-80℃ 2 years in solvent

Solubility Information

DMSO: 29 mg/mL (184.6 mM)

Ethanol: 12 mg/mL (76.4 mM)

Water: 5 mg/mL (31.82 mM), warmed

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature

1. Furuta Y, et al. Antimicrob Agents Chemother. 2002, 46(4), 977-981. 2. Baranovich T, et al. J Virol. 2013, 87(7), 3741-3751. 3. Madelain V, et al. Antiviral Res. 2015, 123, 70-77.

Related Compound Libraries

This product is contained In the following compound libraries：

Approved Drug Library Bioactive Compound Library Inhibitor Library Anti-infection Compound Library Fluorochemical Library

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Ferrous fumarate Sodium Nitroprusside Methylene Blue trihydrate Mercaptopurine Phenethyl alcohol Mecarbinate cis-Anethol Mephenesin

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Answers to questions you may have can be found in the Inhibitor Handling Instructions. Topics include how to prepare stock solutions, how to store Products, and issues that need special attention for cell-based assays and animal experiments.

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.