Shopping Cart

Your shopping cart is currently empty

Famotidine

Name: Famotidine
Brand: TargetMol
SKU: T1627
Price: 50 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

🥰Excellent

Catalog No. T1627Cas No. 76824-35-6

Alias MK-208

Famotidine (MK-208) is a propanimidamide and histamine H2-receptor antagonist with antacid activity. As a competitive inhibitor of histamine H2-receptors on the basolateral membrane of parietal cells, famotidine reduces basal and nocturnal gastric acid secretion, thereby decreasing gastric volume, acidity, and the amount of gastric acid released in response to various stimuli.

Famotidine

Copy Product Info

🥰Excellent

Purity: 99.91%

Catalog No. T1627Alias MK-208Cas No. 76824-35-6

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
2 g	$50	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.91%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Famotidine AI Summary

Famotidine exhibits a range of bioactivities including inhibitory effects against HIV-1 integrase, with inhibition results of less than 50.0% at both 1 mM and 200 µM concentrations. It acts as a histamine H2 receptor antagonist, demonstrated by its ability to reduce the chronotropic response to histamine in guinea pig right atrium with an ED50 of 0.0000027 M and reduction in gastric acid secretion in anesthetized dogs with an ED50 of 0.0087 mg/kg. The compound has a binding affinity (Kd) of 18.2 nM on isolated guinea pig right atrium and shows efficacy in inhibiting various gastric functions including aspirin-induced gastric lesions and gastric acid secretion in rats. Famotidine exhibits an absorption rate of 45.0% in the human GI tract, a logD6.8 of -0.8, and a bioavailability of 49.0%. It also has a total body clearance rate of 6.6 mL/min/kg in humans, with renal clearance rate of 4.42 mL/min/kg, and exhibits an ionization constant (pKa) of 7.1. The compound demonstrates moderate protein binding with a logFu of 0.83 and a volume of distribution at steady state (Vdss) of 1.2 L/kg. Famotidine also shows various other bioactivities including antiviral, antifungal, and antibacterial activities, selective inhibition of human MATE1-mediated transport, liver toxicity, and potential as a histamine H2 radioligand binding antagonist. Additionally, it affects markers of liver function, kidney function, electrolyte balance, glucose levels, and lipid metabolism, suggesting diverse bioactivities affecting multiple physiological systems. Its inhibitory activity includes significant bioactivities towards different enzymes such as Bloom's syndrome helicase, Histone Lysine Methyltransferase G9a, Bacillus subtilis Sfp phosphopantetheinyl transferase, and others, indicating potential therapeutic applications..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Famotidine (MK-208) is a propanimidamide and histamine H2-receptor antagonist with antacid activity. As a competitive inhibitor of histamine H2-receptors on the basolateral membrane of parietal cells, famotidine reduces basal and nocturnal gastric acid secretion, thereby decreasing gastric volume, acidity, and the amount of gastric acid released in response to various stimuli.
Synonyms	MK-208

Chemical Properties

Molecular Weight	337.45
Formula	C₈H₁₅N₇O₂S₃
Cas No.	76824-35-6
Smiles	N(C(=N)N)C1=NC(CSCCC(NS(N)(=O)=O)=N)=CS1
Relative Density.	1.5111 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (740.85 mM), Sonication is recommended.

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.93 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9634 mL	14.8170 mL	29.6340 mL	148.1701 mL
5 mM	0.5927 mL	2.9634 mL	5.9268 mL	29.6340 mL
10 mM	0.2963 mL	1.4817 mL	2.9634 mL	14.8170 mL
20 mM	0.1482 mL	0.7409 mL	1.4817 mL	7.4085 mL
50 mM	0.0593 mL	0.2963 mL	0.5927 mL	2.9634 mL
100 mM	0.0296 mL	0.1482 mL	0.2963 mL	1.4817 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc