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FLI06

Catalog No. T3075 CAS 313967-18-9

Synonyms: FLI 06, FLI-06

FLI-06 is a Notch signaling inhibitor (EC50: 2.3 μM).

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

FLI06, CAS 313967-18-9

Pack Size	Availability	Price/USD
2 mg	In stock	49.00
5 mg	In stock	69.00
10 mg	In stock	101.00
25 mg	In stock	181.00
50 mg	In stock	328.00
100 mg	In stock	571.00
1 mL * 10 mM (in DMSO)	In stock	75.00

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Purity 100.00%

HNMR HPLC COA

Purity 98.00%

COA

Datasheet SDS

Biological Description

Chemical Properties

Storage & Solubility Information

Description	FLI-06 is a Notch signaling inhibitor (EC50: 2.3 μM).
Targets&IC50	Notch
Kinase Assay	EC50 values of the test compounds are calculated from serial dilution series ranging from 200 to 0.1 μM. Cells are seeded in 96-well plates at a density of 5,000 cells per well in 100 μL medium. The next day, 100 μL medium containing each test compound is added. Cells are incubated for 16 h, fixed and processed for automated microscopy. EC50 estimates are calculated using four-parameter log-logistic fit with the package drc[1].

Synonyms	FLI 06 , FLI-06
Purity	100.00%
Molecular Weight	438.52
Formula	C25H30N2O5
CAS No.	313967-18-9

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 6 months

Solubility Information

DMSO: 43.9 mg/mL (100 mM)

Ethanol: 8.8 mg/mL (20 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature

1. Kr?mer A, et al. Nat Chem Biol. 2013, 9(11), 731-738.

Related compound libraries

This product is contained In the following compound libraries：

Bioactive Compound Library Inhibitor Library Anti-Cancer Compound Library Stem Cell Differentiation Compound Library Neuronal Signaling Compound Library Protease Inhibitor Library GPCR Compound Library Wnt/Hedgehog/Notch Compound Library Cancer Cell Differentiation Compound Library Neural Regeneration Compound Library Anti-Aging Compound Library Target-Focused Phenotypic Screening Library HIF-1 Signaling Pathway Compound Library Anti-Neurodegenerative Disease Compound Library Anti-Breast Cancer Compound Library Anti-Alzheimer's Disease Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.