Neuroscience Gamma-secretase FLI06


Catalog No. T3075   CAS 313967-18-9
Synonyms: FLI 06, FLI-06

FLI-06 is a Notch signaling inhibitor (EC50: 2.3 μM).

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FLI06, CAS 313967-18-9
Pack Size Availability Price/USD Quantity
2 mg In stock 49.00
5 mg In stock 69.00
10 mg In stock 101.00
25 mg In stock 181.00
50 mg In stock 328.00
100 mg In stock 571.00
1 mL * 10 mM (in DMSO) In stock 75.00
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Purity 100.00%
Purity 98.00%
Biological Description
Chemical Properties
Storage & Solubility Information
Description FLI-06 is a Notch signaling inhibitor (EC50: 2.3 μM).
Targets&IC50 Notch
Kinase Assay EC50 values of the test compounds are calculated from serial dilution series ranging from 200 to 0.1 μM. Cells are seeded in 96-well plates at a density of 5,000 cells per well in 100 μL medium. The next day, 100 μL medium containing each test compound is added. Cells are incubated for 16 h, fixed and processed for automated microscopy. EC50 estimates are calculated using four-parameter log-logistic fit with the package drc[1].
Synonyms FLI 06 , FLI-06
Purity 100.00%
Molecular Weight 438.52
Formula C25H30N2O5
CAS No. 313967-18-9


Powder: -20°C for 3 years

In solvent: -80°C for 6 months

Solubility Information

DMSO: 43.9 mg/mL (100 mM)

Ethanol: 8.8 mg/mL (20 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )


References and Literature
1. Kr?mer A, et al. Nat Chem Biol. 2013, 9(11), 731-738.

Related compound libraries

This product is contained In the following compound libraries:
Bioactive Compound Library Inhibitor Library Anti-Cancer Compound Library Stem Cell Differentiation Compound Library Neuronal Signaling Compound Library Protease Inhibitor Library GPCR Compound Library Wnt/Hedgehog/Notch Compound Library Cancer Cell Differentiation Compound Library Neural Regeneration Compound Library Anti-Aging Compound Library Target-Focused Phenotypic Screening Library HIF-1 Signaling Pathway Compound Library Anti-Neurodegenerative Disease Compound Library Anti-Breast Cancer Compound Library Anti-Alzheimer's Disease Compound Library

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