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Eltanexor Z-isomer

Catalog No. T11766 CAS 1642300-78-4

Synonyms: KPT-8602 (Z-isomer)

Eltanexor Z-isomer exhibits different inhibitory effects on Z138, MM15, 3T3 cell lines, with IC50s of 100 nM-50 μM, < 100 nM, < 30 μM, respectively.Eltanexor Z-isomer is the less active isomer of KPT-8602. KPT-8602 is a potent CRM1 inhibitor.

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Eltanexor Z-isomer, CAS 1642300-78-4

Pack Size	Availability	Price/USD
2 mg	5 days	$ 196.00
25 mg	6-8 weeks	$ 877.00
50 mg	6-8 weeks	$ 1,140.00
100 mg	6-8 weeks	$ 1,730.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Eltanexor Z-isomer exhibits different inhibitory effects on Z138, MM15, 3T3 cell lines, with IC50s of 100 nM-50 μM, < 100 nM, > 30 μM, respectively.Eltanexor Z-isomer is the less active isomer of KPT-8602. KPT-8602 is a potent CRM1 inhibitor.

Synonyms	KPT-8602 (Z-isomer)
Molecular Weight	428.29
Formula	C17H10F6N6O
CAS No.	1642300-78-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (116.74 mM), Sonication is recommended.

References and Literature

1. Vercruysse T et al. The second-generation exportin-1 inhibitor KPT-8602 demonstrates potent activity against acute lymphoblastic leukemia. Clin Cancer Res. 2016 Oct 25. 2. Hing ZA et al. Next-generation XPO1 inhibitor shows improved efficacy and in vivo tolerability in hematological malignancies. Leukemia. 2016 Jun 21. 3. Etchin J et al. KPT-8602, a second-generation inhibitor of XPO1-mediated nuclear export, is well tolerated and highly active against AML blasts and leukemia-initiating cells. Leukemia. 2016 Jun 24.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Eltanexor Z-isomer 1642300-78-4 Others Eltanexor Z isomer KPT-8602 KPT-8602 (Z-isomer) Eltanexor Zisomer KPT 8602 KPT8602 Z-isomer inhibitor inhibit

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