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Eltanexor

Catalog No. T11766L CAS 1642300-52-4

Synonyms: ONO-7706, KPT-8602, ATG-016

Eltanexor (ONO-7706) is an orally active exportin-1 (XPO1) inhibitor. It has effective anti-leukemic activity. Eltanexor inhibits XPO1-dependent nuclear export (EC50=60.9 nM) by directly targeting XPO1. Eltanexor causes caspase-dependent apoptosis in a panel of leukemic cell lines.

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Eltanexor, CAS 1642300-52-4

Pack Size	Availability	Price/USD
1 mg	In stock	$ 77.00
5 mg	In stock	$ 237.00
10 mg	In stock	$ 347.00
25 mg	In stock	$ 589.00
50 mg	In stock	$ 842.00
100 mg	In stock	$ 1,160.00
500 mg	In stock	$ 2,330.00
1 mL * 10 mM (in DMSO)	In stock	$ 223.00

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Purity: 99.76%

Purity: 99.6%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Eltanexor (ONO-7706) is an orally active exportin-1 (XPO1) inhibitor. It has effective anti-leukemic activity. Eltanexor inhibits XPO1-dependent nuclear export (EC50=60.9 nM) by directly targeting XPO1. Eltanexor causes caspase-dependent apoptosis in a panel of leukemic cell lines.
Targets&IC50	XPO1:60.9 nM(EC50)
In vitro	Eltanexor (KPT-8602) (1 nM; 16 hours) causes apoptosis in leukemia cell lines. KPT-8602 (2-6 nM; 72 hours) decreases cell viability in leukemia cell lines (EC50s ranging from 25 to 145 nM).
In vivo	KPT-8602 (15 mg/kg; oral gavage; daily for 12 days) displays effective anti-lymphoblastic leukemia activity.

Synonyms	ONO-7706, KPT-8602, ATG-016
Molecular Weight	428.29
Formula	C17H10F6N6O
CAS No.	1642300-52-4

Storage

store at low temperature,keep away from direct sunlight

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 80 mg/mL (186.78 mM)

H2O: < 0.1 mg/mL (insoluble)

References and Literature

1. Vercruysse T et al. The second-generation exportin-1 inhibitor KPT-8602 demonstrates potent activity against acute lymphoblastic leukemia. Clin Cancer Res. 2016 Oct 25.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Eltanexor 1642300-52-4 Others ONO7706 ATG 016 ONO 7706 ONO-7706 KPT-8602 KPT 8602 KPT8602 ATG016 ATG-016 inhibitor inhibit

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