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Elimusertib hydrochloride(1876467-74-1 free base)

Catalog No. T10468 CAS T10468

Synonyms: BAY-1895344 hydrochloride

Elimusertib hydrochloride(1876467-74-1 free base) (BAY-1895344 hydrochloride) is a effective, orally available and selective ATR inhibitor with anti-tumor activity.

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Elimusertib hydrochloride(1876467-74-1 free base) Chemical Structure

Elimusertib hydrochloride(1876467-74-1 free base), CAS T10468

Pack Size	Availability	Price/USD
1 mg	In stock	$ 51.00
2 mg	In stock	$ 71.00
5 mg	In stock	$ 135.00
10 mg	In stock	$ 205.00
25 mg	In stock	$ 413.00
50 mg	In stock	$ 613.00
100 mg	In stock	$ 873.00
500 mg	In stock	$ 1,780.00
1 mL * 10 mM (in DMSO)	In stock	$ 146.00

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Purity: 99.86%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Elimusertib hydrochloride(1876467-74-1 free base) (BAY-1895344 hydrochloride) is a effective, orally available and selective ATR inhibitor with anti-tumor activity.
Targets&IC50	ATR:7 nM
In vitro	Elimusertib hydrochloride potently inhibits the proliferation of a broad spectrum of human tumor cell lines (median IC50: 78 nM). BAY-1895344 potently suppresses NSC-32065-induced H2AX phosphorylation (IC50: 36 nM) [1].
In vivo	In a variety of xenograft models of ovarian and colorectal cancer, Elimusertib hydrochloride shows potent anti-tumor efficacy in monotherapy and causes complete tumor remission in mantle cell lymphoma models [2].

Synonyms	BAY-1895344 hydrochloride
Molecular Weight	411.89
Formula	C20H22ClN7O
CAS No.	T10468

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (121.39 mM), Sonication and heating are recommended.

H2O: 48 mg/mL (116.53 mM), Sonication is recommended.

References and Literature

1. Ulrich T. Luecking, et al. Abstract 983: Identification of potent, highly selective and orally available ATR inhibitor BAY 1895344 with favorable PK properties and promising efficacy in monotherapy and combination in preclinical tumor models. Cancer Research. July 2017 Volume 77, Issue 13 Supplement. 2. Antje Margret Wengner, et al. Abstract 836: ATR inhibitor BAY 1895344 shows potent anti-tumor efficacy in monotherapy and strong combination potential with the targeted alpha therapy Radium-223 dichloride in preclinical tumor models. Cancer Research. July 2017 Volume 77, Issue 13 Supplement 3. Ulrich Lücking, et al. Damage Incorporated: Discovery of the Potent, Highly Selective, Orally Available ATR Inhibitor BAY 1895344 with Favorable Pharmacokinetic Properties and Promising Efficacy in Monotherapy and in Combination Treatments in Preclinical Tumor Models. J Med Chem. 2020 Jul 9;63(13):7293-7325.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Drug Library Kinase Inhibitor Library Inhibitor Library Anti-Cancer Clinical Compound Library Anti-Cancer Active Compound Library Drug Repurposing Compound Library Neural Regeneration Compound Library Anti-Lung Cancer Compound Library Clinical Compound Library Glycolysis Compound Library

Related Products

Related compounds with same targets

ATR-IN-29 (Z)-Mirin Camonsertib ATR-IN-24 M3541 AZ20 Dactolisib VE-821

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Elimusertib hydrochloride(1876467-74-1 free base) T10468 DNA Damage/DNA Repair PI3K/Akt/mTOR signaling ATM/ATR BAY1895344 Hydrochloride BAY 1895344 Hydrochloride BAY-1895344 hydrochloride Elimusertib hydrochloride(1876467 74 1 free base) Elimusertib hydrochloride(1876467741 free base) BAY-1895344 Hydrochloride inhibitor inhibit

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