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Eicosapentaenoic acid ethyl ester

Catalog No. T7068 CAS 86227-47-6

Synonyms: Icosapent ethyl, EPA ethyl ester, Ethyl eicosapentaenoate

Eicosapentaenoic acid ethyl ester (Ethyl eicosapentaenoate) is an omega-3 fatty acid.

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Eicosapentaenoic acid ethyl ester Chemical Structure

Eicosapentaenoic acid ethyl ester, CAS 86227-47-6

Pack Size	Availability	Price/USD	Quantity
50 mg	In stock	$ 50.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 98.13%

Purity: 95%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Eicosapentaenoic acid ethyl ester (Ethyl eicosapentaenoate) is an omega-3 fatty acid.

In vivo

Icosapent ethyl (IPE) 4 g/day significantly reduced large VLDL, total LDL, small LDL, and total HDL particle concentrations and VLDL particle size in patients with TG 500 mg/dL.Changes in VLDL particle concentration and size reflect the TG-lowering effects of eicosapentaenoic acid.?The reduction in LDL particle concentration with IPE is novel among ω-3 therapies and is consistent with the previously reported reduction in apolipoprotein B and lack of LDL-C increase with IPE in patients with very high TG levels.

Synonyms	Icosapent ethyl, EPA ethyl ester, Ethyl eicosapentaenoate
Molecular Weight	330.5
Formula	C22H34O2
CAS No.	86227-47-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 33.33 mg/mL (100.85 mM), Sonication is recommended.

Ethanol: 50 mg/mL (151.29 mM), Sonication is recommended.

References and Literature

1. Bays H E , Braeckman R A , Ballantyne C M , et al. Icosapent ethyl, a pure EPA omega-3 fatty acid: effects on lipoprotein particle concentration and size in patients with very high triglyceride levels (the MARINE study).[J]. Journal of Clinical Lipidology, 2012, 6(6):565-572. 2. Bays HE, et al. Eicosapentaenoic acid ethyl ester (AMR101) therapy in patients with very high triglyceride levels (from theMulti-center, plAcebo-controlled, Randomized, double-blINd, 12-week study with an open-label Extension[MARINE] trial). Am J Cardiol. 2011 Sep 1;108(5):682-690. 3. Jacobson TA. A new pure ω-3 eicosapentaenoic acid ethyl ester (AMR101) for the management of hypertriglyceridemia: the MARINE trial. Expert Rev Cardiovasc Ther. 2012 Jun;10(6):687-695.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Human Endogenous Metabolite Compound Library Plus Bioactive Compound Library FDA-Approved & Pharmacopeia Drug Library Natural Product Library for HTS FDA-Approved Drug Library Human Metabolite Library Approved Drug Library Anti-Cardiovascular Disease Compound Library Natural Product Library

Related Products

Related compounds with same targets

4-Acetamidobutanoic acid Pyrroloquinoline quinone disodium salt Benazeprilat Phenylglyoxylic acid 4-Pentenoic acid Cysteinylglycine acetate L-5-Hydroxytryptophan Adipic acid

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Eicosapentaenoic acid ethyl ester 86227-47-6 Metabolism Others Endogenous Metabolite Icosapent ethyl Inhibitor inhibit EPA ethyl ester Ethyl eicosapentaenoate inhibitor

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