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Ecteinascidin 770

Catalog No. T11150 CAS 114899-80-8

Synonyms: Ecteinascidine 770, Et-770

Ecteinascidin 770 (ET-770) inhibits U373MG cells and is a 1,2,3, 4-tetrahydroisoquinoline alkaloid with strong anticancer activity.IC50 is 4.83 nM.

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Ecteinascidin 770, CAS 114899-80-8

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Description	Ecteinascidin 770 (ET-770) inhibits U373MG cells and is a 1,2,3, 4-tetrahydroisoquinoline alkaloid with strong anticancer activity.IC50 is 4.83 nM.
Targets&IC50	U373MG cells:4.83 nM
In vitro	ET-770 (Ecteinascidin 770) significantly enhances the anoikis response in human lung cancer H23 and H460 cells by activating p53 protein. This activation leads to the down-regulation of anti-apoptotic myeloid cell leukemia sequence-1 (MCL1) and up-regulation of BCL2-associated X protein (BAX), while B-cell lymphoma-2 (BCL2) proteins remain largely unaffected. Additionally, ET-770 induces apoptosis in U373MG glioblastoma cells, with an IC50 value of 4.83 nM after a 72-hour treatment, as determined by the MTT assay. The IC50 values for HCT116, QG56, and DU145 human cell lines are found to be 0.6, 2.4, and 0.81 nM, respectively, showcasing its apoptotic effectiveness across various cell types in a dose-dependent manner.

Synonyms	Ecteinascidine 770, Et-770
Molecular Weight	770.85
Formula	C40H42N4O10S
CAS No.	114899-80-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Tabunoki H, et al. Molecular network profiling of U373MG human glioblastoma cells following induction of apoptosis by novel marine-derived anti-cancer 1,2,3,4-tetrahydroisoquinoline alkaloids. Cancer Cell Int. 2012 Apr 11;12(1):14. 2. Saktrakulkla P, et al. Chemistry of ecteinascidins. Part 3: preparation of 2'-N-acyl derivatives of ecteinascidin 770 and evaluation of cytotoxicity. Bioorg Med Chem. 2011 Aug 1;19(15):4421-36. 3. Powan P, et al. Ecteinascidin 770, a tetrahydroisoquinoline alkaloid, sensitizes human lung cancer cells to anoikis. Anticancer Res. 2013 Feb;33(2):505-12.

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Keywords

Ecteinascidin 770 114899-80-8 Others Ecteinascidine 770 Et-770 inhibitor inhibit

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