Microbiology&virology Antifection Econazole nitrate

Econazole nitrate

Catalog No. T0444L   CAS 24169-02-6
Synonyms: NSC 243115
Purity 99.40% Datasheet MSDS

Econazole nitrate (Spectazole) is an imidazole class antifungal medicine.

Econazole nitrate, CAS 24169-02-6
Pack Size Availability Price/USD Quantity
100 mg In stock 35.00
200 mg In stock 42.00
500 mg In stock 50.00
1 mL * 10 mM (in DMSO) In stock 54.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Econazole nitrate (Spectazole) is an imidazole class antifungal medicine.
Targets&IC50 14-α Demethylase,  
In vitro Econazole nitrate is an effective inducer of micronuclei over a narrow dose range in cell lines V79, XEM2 and XEMd-MZ (expresses CYP1A2). [1] Econazole nitrate inhibits the proliferation of MCF-7 cells in a time- and dose-dependent manner by MTT method and colony forming assay. Econazole nitrate results in typical characteristics of apoptosis including the morphological changes and DNA fragmentation in MCF-7 cells. Econazole nitrate results in the decrease expression of procaspase-3, procaspase-9 and bcl-2. [2] Econazole inhibits ADP-ribose-activated currents in HEK-293 cells expressing recombinant human TRPM2 (hTRPM2). Econazole produces an essentially complete inhibition of the TRPM2-mediated current. [3] Econazole (25-50 mM) partially inhibits capacitative Ca2+ entry induced by cyclopiazonic acid, another endoplasmic reticulum Ca2+ pump inhibitor. Econazole induces Ca2+ influx via two separate pathways: one is sensitive to La3+, the other is not. [4] Econazole reversibly inhibits (Bu)(2)cAMP-stimulated progesterone production in a dose- and time-dependent manner in MA-10 cells without affecting total protein synthesis or P450(scc) and 3beta-hydroxysteroid dehydrogenase (3beta-HSD) enzyme expression or activity. [5] Econazole is a store-operated Ca2+ channel antagonist which induces cytotoxic cell death of leukemia. Econazole (5-20 mM) arrests human colon cancer cells at the G0/G1 phase of the cell cycle. Econazole induces COLO 205 cells apoptosis evidenced by ladder formation in DNA fragmentation assay and sub-G1 peak. [6]
Synonyms NSC 243115
Purity 99.00%
Appearance solid
Molecular Weight 444.70
Formula C18H15Cl3N2O·HNO3
CAS No. 24169-02-6


-20℃ 3 years powder

-80℃ 2 years in solvent

Solubility Information

DMSO: 82 mg/mL (184.4 mM)

Ethanol: 5 mg/mL (11.24 mM)

Water: <1 mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )


References and Literature
1. Ferrer-Villada T, et al. Eur J Pharmacol,2006, 531(1-3), 1-8. 2. Sun J, et al. Iran J Pharm Res,2014, 13(4), 1327-1334. 3. Hill K, et al. Naunyn Schmiedebergs Arch Pharmacol,2004, 370(4), 227-237. 4. Jan CR, et al. Biochim Biophys Acta,1999, 1448(3), 533-542. 5. Walsh LP, et al. J Steroid Biochem Mol Biol,2000, 75(4-5), 229-236. 6. Ho YS, et al. Food Chem Toxicol,2005, 43(10), 1483-1495.

Related Compound Libraries

This product is contained In the following compound libraries:
Approved Drug Library Bioactive Compound Library Inhibitor Library Anti-cancer Compound Library Anti-infection Compound Library FDA-approved Drug Library Immunology/Inflammation Compound Library Antibiotics Library Antifungal Compound Library

Related Products

Related compounds with same targets
Voriconazole Vagistat Miconazole Econazole Econazole nitrate Clotrimazole Rifampicin Ganciclovir

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