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EB-47

Catalog No. T11143 CAS 366454-36-6

EB-47 mimics the substrate NAD+ and extends from the nicotinamide to the adenosine subsite.EB-47, a potent and selective PARP-1/ARTD-1 inhibitor with an IC50 value of 45 nM, shows modest potency against ARTD5 with an IC50 value of 410 nM.

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EB-47, CAS 366454-36-6

Pack Size	Availability	Price/USD
1 mg	In stock	$ 62.00
5 mg	In stock	$ 133.00
10 mg	In stock	$ 223.00
25 mg	In stock	$ 397.00
50 mg	In stock	Inquiry
1 mL * 10 mM (in DMSO)	In stock	$ 179.00

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Purity: 99.86%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	EB-47 mimics the substrate NAD+ and extends from the nicotinamide to the adenosine subsite.EB-47, a potent and selective PARP-1/ARTD-1 inhibitor with an IC50 value of 45 nM, shows modest potency against ARTD5 with an IC50 value of 410 nM.
Targets&IC50	ARTD1/PARP1:45 nM
In vitro	The inhibitory effect of EB-47 on CdPARP and HsPARP was 0.86 and 1.0uM with IC50 value respectively, and the inhibitory effect on CdPARP was over 50%[1].
In vivo	EB-47, at a concentration of 2 μM for a duration of 5 days, reduces the number of embryo implantation sites and the quantity of blastocysts observed on day 5. PARP1 is involved in the embryo implantation process[1].

Molecular Weight	537.53
Formula	C24H27N9O6
CAS No.	366454-36-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 60 mg/mL (111.62 mM)

References and Literature

1. Haikarainen T, et al. Evaluation and Structural Basis for the Inhibition of Tankyrases by PARP Inhibitors.ACS Med Chem Lett. 2013 Nov 20;5(1):18-22. 2. García-Saura AG, et al. Comparative inhibitory profile and distribution of bacterial PARPs, using Clostridioides difficile CD160 PARP as a model. Sci Rep. 2018 May 23;8(1):8056. 3. Joshi A, et al.PARP1 during embryo implantation and its upregulation by oestradiol in mice.Reproduction. 2014 Jun;147(6):765-80. 4. Jagtap PG, et al. The discovery and synthesis of novel adenosine substituted 2,3-dihydro-1H-isoindol-1-ones: potent inhibitors of poly(ADP-ribose) polymerase-1 (PARP-1).Bioorg Med Chem Lett. 2004 Jan 5;14(1):81-5.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Pancreatic Cancer Compound Library DNA Damage & Repair Compound Library Epigenetics Compound Library Anti-Ovarian Cancer Compound Library Bioactive Compounds Library Max Anti-Cancer Compound Library Bioactive Compound Library

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E7449 UPF 1069 VPC-70063 Rucaparib E7016 Glycoborinine 4-amino-1,8-Naphthalimide Niraparib tosylate

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

EB-47 366454-36-6 Chromatin/Epigenetic DNA Damage/DNA Repair PARP EB47 EB 47 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.