Powder: -20°C for 3 years | In solvent: -80°C for 1 year
E1R is a positive sigma-1 receptor (Sig1R PAM) allosteric modulator. It has a cognition-enhancing activity.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | 5 days | $ 242.00 | |
25 mg | 8-10 weeks | $ 987.00 | |
50 mg | 8-10 weeks | $ 1,360.00 | |
100 mg | 8-10 weeks | $ 1,860.00 | |
1 mL * 10 mM (in DMSO) | 5 days | $ 253.00 |
Description | E1R is a positive sigma-1 receptor (Sig1R PAM) allosteric modulator. It has a cognition-enhancing activity. |
In vitro | E1R (10?μM) does not displace the radioligand. However, in Jurkat cells, it instead increases the specific binding of a non-selective radioligand ([3H]1,3-di(2-tolyl)guanidine) for the sigma receptor by 38%. The only target for E1R (inhibition or enhancement of radioligand binding exceeding 20%) is the sigma receptor. |
In vivo | E1R (0.1-10?mg/kg; i.p. 60?min before the training session) treatment obviously improves cognitive function in a dose-related manner in mice. E1R demonstrates efficacy against scopolamine-induced cholinergic dysfunction in mice. |
Molecular Weight | 232.28 |
Formula | C13H16N2O2 |
CAS No. | 1301211-78-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 60 mg/mL (258.31 mM), sonification is recommended.
You can also refer to dose conversion for different animals. More
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E1R 1301211-78-8 Others E-1R inhibitor inhibit