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Dimethyl-SGD-1882

Catalog No. T11046 CAS T11046

Synonyms: Dimethyl-PBD dimer

Dimethyl-SGD-1882 (Dimethyl-PBD dimer) is a highly efficient DNA alkylating agent used as antibody-drug conjugate (ADC) cytotoxin. PBD Dimer is a DNA alkylating agent that inhibits DNA replication.

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Dimethyl-SGD-1882, CAS T11046

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Biological Description

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Description

Dimethyl-SGD-1882 (Dimethyl-PBD dimer) is a highly efficient DNA alkylating agent used as antibody-drug conjugate (ADC) cytotoxin. PBD Dimer is a DNA alkylating agent that inhibits DNA replication.

In vitro

The unique structure of Pyrrolobenzodiazepine (PBD) dimer contains two alkylated imines. In addition to monoalkylated adducts, it can also form inter-chain or intra-chain DNA cross-links, therefore Compared with PBD, it has greater DNA stability. Due to the possibility of other types of DNA adducts and higher adduct stability, C8-linked PBD dimers usually have significantly higher cytotoxicity, antitumor activity, and antibacterial activity than PBD monomers And one of the reagents, SJG-136, has entered clinical trials for stage II ovarian cancer and leukemia. In addition, because the related PBD dimer has significant cytotoxicity, it is currently being used as a payload of antibody-drug conjugates (ADC).

Synonyms	Dimethyl-PBD dimer
Molecular Weight	753.84
Formula	C44H43N5O7
CAS No.	T11046

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Mantaj J, et al. From Anthramycin to Pyrrolobenzodiazepine (PBD)-Containing Antibody-Drug Conjugates (ADCs). Angew Chem Int Ed Engl. 2017 Jan 9;56(2):462-488.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Dimethyl-SGD-1882 T11046 Others DimethylSGD1882 Dimethyl-SGD 1882 Dimethyl-SGD1882 Dimethyl SGD 1882 Dimethyl-PBD dimer inhibitor inhibit

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