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Membrane transporter/Ion channel Calcium Channel Diltiazem hydrochloride

Diltiazem hydrochloride

Catalog No. T0112   CAS 33286-22-5
Synonyms: CRD-401, Diltiazem HCl, RG 83606 HCl
Purity 99.65% Datasheet MSDS

Diltiazem Hydrochloride is a benzothiazepine calcium channel blocking agent with vasodilating action due to its antagonism of the actions of CALCIUM ion on membrane functions.

Diltiazem hydrochloride, CAS 33286-22-5
Pack Size Availability Price/USD Quantity
50 mg In stock 28.00
100 mg In stock 42.00
500 mg In stock 50.00
1 g In stock 59.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Diltiazem Hydrochloride is a benzothiazepine calcium channel blocking agent with vasodilating action due to its antagonism of the actions of CALCIUM ion on membrane functions.
Targets&IC50 Calcium Channel,  
Synonyms CRD-401, Diltiazem HCl, RG 83606 HCl
Purity 98.00%
Appearance solid
Molecular Weight 450.98
Formula C22H27ClN2O4S
CAS No. 33286-22-5

Storage

-20℃ 3 years powder

-80℃ 2 years in solvent

Solubility Information

Ethanol: 4 mg/mL (8.86 mM)

Water: 100 mg/mL (221.74 mM)

DMSO: 12.4 mg/mL (27.5 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Kraus RL, et al. Molecular mechanism of diltiazem interaction with L-type Ca2+ channels. J Biol Chem. 1998 Oct 16;273(42):27205-12. 2. van Breemen C, et al. The mechanism of inhibitory action of diltiazem on vascular smooth muscle contractility. J Pharmacol Exp Ther. 1981 Aug;218(2):459-63. 3. Chiesi M, et al. Stereospecific action of diltiazem on the mitochondrial Na-Ca exchange system and on sarcolemmal Ca-channels. Biochem Pharmacol. 1987 Sep 1;36(17):2735-40. 4. Freitas F, et al. Cardiac microvascular rarefaction in hyperthyroid rats is reversed by losartan, diltiazem, and propranolol. Fundam Clin Pharmacol. 2015 Feb;29(1):31-40. 5. Sato M, et al. Hypotensive effects of diltiazem hydrochloride in the normotensive, spontaneously hypertensive and renal hypertensive rats (author's transl). Nihon Yakurigaku Zasshi. 1979 Mar;75(2):99-106.

Related Compound Libraries

This product is contained In the following compound libraries:
Approved Drug Library Bioactive Compound Library Inhibitor Library Ion Channel Inhibitor Library FDA-approved Drug Library Cardiotoxicity Compound Library Anti-Cardiovascular Disease Compound Library

Related Products

Related compounds with same targets
Dantrolene sodium salt Diltiazem hydrochloride Nitrendipine Azelnidipine Felodipine Nisoldipine Levetiracetam Manidipine dihydrochloride

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