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Metabolism NADPH Dicumarol

Dicumarol

Catalog No. T0809   CAS 66-76-2
Synonyms: Dicoumarol

Dicumarol is a hydroxycoumarin originally isolated from molding sweet-clover hay, with anticoagulant and vitamin K depletion activities. Dicumarol is a competitive inhibitor of vitamin K epoxidereductase; thus, it inhibits vitamin K recycling and causes depletion of active vitamin K in blood. This prevents the formation of the active form of prothrombin and several other coagulant enzymes, and inhibits blood clotting.

Dicumarol, CAS 66-76-2
Pack Size Availability Price/USD Quantity
25 mg In stock 36.00
50 mg In stock 47.00
100 mg In stock 58.00
200 mg In stock 98.00
1 mL * 10 mM (in DMSO) In stock 50.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Dicumarol is a hydroxycoumarin originally isolated from molding sweet-clover hay, with anticoagulant and vitamin K depletion activities. Dicumarol is a competitive inhibitor of vitamin K epoxidereductase; thus, it inhibits vitamin K recycling and causes depletion of active vitamin K in blood. This prevents the formation of the active form of prothrombin and several other coagulant enzymes, and inhibits blood clotting.
Targets&IC50 NQO1 : ic50 0.37μM,   PDK1 : ic50 19.42μM,  
Synonyms Dicoumarol
Purity 99.90%
Molecular Weight 336.29
Formula C19H12O6
CAS No. 66-76-2

Storage

0-4℃ for short term (days to weeks), or -20℃ for long term (months).

Solubility Information

DMSO: 62 mg/mL (184.4 mM)

Ethanol: 62 mg/mL (184.4 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Jaiswal AK. Arch Biochem Biophys. 2000, 375(1):62-8.

Related compound libraries

This product is contained In the following compound libraries:
Approved Drug Library Bioactive Compound Library Inhibitor Library Natural Compound Library for HTS Anti-cancer Compound Library PI3K-AKT-mTOR Compound Library FDA-approved Drug Library Selected Plant-sourced Compound Library Kinase Inhibitor Library Anti-Metabolism Disease Compound Library Anti-Cardiovascular Disease Compound Library Anti-cancer Metabolism Compound Library

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