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Endocrinology/Hormones Opioid Receptor Dextromethorphan HBr monohydrate

Dextromethorphan HBr monohydrate

Catalog No. T0262   CAS 6700-34-1
Synonyms: Dextromethorphan hydrobromide hydrate, Dextromethorphan hydrobromide monohydrate
Purity 99.70% Datasheet

Methyl analog of DEXTRORPHAN that shows high-affinity binding to some areas of the brain, including the medullary cough center. This compound is an NMDA receptor antagonist (receptors, N-METHYL-D-ASPARTATE) and a non-competitive channel blocker. It is one of the extensively used antitussives and is also used in the research of the relationship of glutamate receptors with neurotoxicity.

Dextromethorphan HBr monohydrate, CAS 6700-34-1
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100 mg In stock 88.00
200 mg In stock 130.00
500 mg In stock 270.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Methyl analog of DEXTRORPHAN that shows high-affinity binding to some areas of the brain, including the medullary cough center. This compound is an NMDA receptor antagonist (receptors, N-METHYL-D-ASPARTATE) and a non-competitive channel blocker. It is one of the extensively used antitussives and is also used in the research of the relationship of glutamate receptors with neurotoxicity.
Targets&IC50 nAChR,   δ-opioid receptor,   κ-opioid receptor,   μ-opioid receptor,  
Cell Research
DC cells at a density of 3 × 105 cells/mL are cultured in the presence or absence of DXM (50 μM) for 1 h followed by stimulation with 100 ng/mL LPS. The control group is treated with PBS alone. After LPS stimulation for 6 h, the medium is removed, and culture medium containing 5 μM DCFDA is added under low-light conditions. The cells are incubated for 30 min at 37°C, and the amount of ROS is analyzed by flow cytometry. (Only for Reference)
Cell lines: Dendritic cells
Animal Research
Animal Model: The fedark Agouti (DA) rat
Synonyms Dextromethorphan hydrobromide hydrate, Dextromethorphan hydrobromide monohydrate
Purity 99.70%
Appearance solid
Molecular Weight 370.32
Formula C18H25NO·HBr·H2O
CAS No. 6700-34-1

Storage

-20℃ 3 years powder

-80℃ 2 years in solvent

Solubility Information

DMSO: 199.8 mM

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Zysset T, et al. Biochem Pharmacol. 1988, 37(16):3155-3160. 2. Chen DY, et al. Clin Dev Immunol. 2013:125643.

Related Compound Libraries

This product is contained In the following compound libraries:
Approved Drug Library Bioactive Compound Library FDA-approved Drug Library

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