store under nitrogen
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DO-264 is an inhibitor of autohydrolase structural domain 12 (ABHD12) (IC50: 11 nM) and an inhibitor of cellular LysoPS degradation that enhances LPS-induced phagocytosis.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
50 mg | 6-8 weeks | $ 747.00 | |
100 mg | 6-8 weeks | $ 1,240.00 |
Description | DO-264 is an inhibitor of autohydrolase structural domain 12 (ABHD12) (IC50: 11 nM) and an inhibitor of cellular LysoPS degradation that enhances LPS-induced phagocytosis. |
Targets&IC50 | ABHD12:11 nM |
In vitro | DO-264 elevated the lyso-PS and 20:4 PS content of primary human macrophages[1]. |
In vivo | Mice treated with DO-264 exhibited a dose-dependent increase in brain lyso-PS and 20:4 PS content, which qualitatively resembled changes observed in ABHD12(-/-) mice. Additionally, both ABHD12(-/-) and DO-264-treated mice displayed exacerbated immunopathology following infection with the lymphocytic choriomeningitis virus (LCMV) clone 13, resulting in severe inflammatory lung damage, heightened chemokine production, and, in some cases, death.[1]. |
Molecular Weight | 558.4 |
Formula | C23H20Cl2F3N5O2S |
CAS No. | 2301866-59-9 |
store under nitrogen
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 80 mg/mL (143.27 mM)
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
DO-264 2301866-59-9 Others DO264 DO 264 inhibitor inhibit