Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Cytochalasin H ((16-Benzyl-5,12-dihydroxy-5,7,14-trimethyl-13-methylidene-18-oxo-17-azatricyclo[9.7.0.01,15]octadeca-3,9-dien-2-yl) acetate) is a potent inhibitor of actin incorporation into filaments.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 166.00 | |
5 mg | In stock | $ 397.00 | |
10 mg | In stock | $ 597.00 | |
25 mg | In stock | $ 973.00 | |
50 mg | In stock | $ 1,290.00 | |
100 mg | In stock | $ 1,770.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 729.00 |
Description | Cytochalasin H ((16-Benzyl-5,12-dihydroxy-5,7,14-trimethyl-13-methylidene-18-oxo-17-azatricyclo[9.7.0.01,15]octadeca-3,9-dien-2-yl) acetate) is a potent inhibitor of actin incorporation into filaments. |
In vitro | Cytochalasin H significantly inhibited angiogenesis in vitro and in vivo, and suppressed the hemoglobin content and HIF-1α and VEGF protein expression in xenografted NSCLC tissues of nude mice. Meanwhile, Cytochalasin H inhibited the secretion of VEGF protein and the expression of HIF-1α protein in A549 and H460 cells. Moreover, Cytochalasin H had a significant inhibitory effect on VEGF mRNA expression but had no effect on HIF-1α mRNA expression, and Cytochalasin H inhibited HIF-1α protein expression by promoting the degradation of HIF-1α protein in A549 and H460 cells. Additionally, CyH dramatically inhibited AKT, P70S6K, and ERK1/2 activation in A549 and H460 cells. |
Synonyms | (16-Benzyl-5,12-dihydroxy-5,7,14-trimethyl-13-methylidene-18-oxo-17-azatricyclo[9.7.0.01,15]octadeca-3,9-dien-2-yl) acetate |
Molecular Weight | 493.63 |
Formula | C30H39NO5 |
CAS No. | 53760-19-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (101.29 mM)
You can also refer to dose conversion for different animals. More
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Cytochalasin H 53760-19-3 Proteases/Proteasome MMP (16-Benzyl-5,12-dihydroxy-5,7,14-trimethyl-13-methylidene-18-oxo-17-azatricyclo[9.7.0.01,15]octadeca-3,9-dien-2-yl) acetate inhibitor inhibit