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Catechin

Catalog No. T0822 CAS 154-23-4

Synonyms: Catechuic acid, (+)-Catechin, Cianidanol, D-Catechin, Catechinic acid

Catechin((+)-Catechin; D-Catechin) is a flavan-3-ol, a type of natural phenol and Antioxidant.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Catechin, CAS 154-23-4

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Catechin((+)-Catechin; D-Catechin) is a flavan-3-ol, a type of natural phenol and antioxidant.
Targets&IC50	COX-2:130 μM, COX-1:80 μM
In vitro	The catechin flavonoid reduces proliferation and induces apoptosis of murine lymphoma cells LB02 through modulation of antiapoptotic proteins[1]. Treatment of human prostate cancer cells with catechin induces apoptosis and results in effects on a variety of survival signals suggesting the potential of these compounds as chemopreventive agents for prostate cancer[2]. Catechin is well known to inhibit cyclooxygenase activity with reported IC50 values ranging from 4O μM to 943 μM. It has also been reported to act as an inhibitor of COX-1 and COX-2 with IC50 of about 80 μM and 130 μM[3].
In vivo	Dietary catechin significantly delayed tumor onset[5]. Continued intake of catechin, a potential antioxidant, prevents memory regression and DNA oxidative damage in senescence-accelerated (SAMP10) mice. It does not prolong the lifetime of SAMP10 mice, but it does delay brain senescence[6]. (+)-Catechin inhibits intestinal tumor formation and suppresses Focal adhesion kinase activation in the Min/+ Mouse[7].
Cell Research	LB02 cells were resuspended in RPMI 10% FBS in a concentration of 5x105 cells/mL. The cultures were performed in 96-well round-bottomed microtitre plates in presence of different concentrations of catechin or rutin (10, 50, 100 or 200 μg/mL). After 48 h at 37 ºC in a humidified atmosphere with 5% CO2 in the air, cultures were pulsed with 1 μCi of 3H-thymidine/well and maintained for an additional 18 h period prior to a semiautomatic method harvest. (Only for Reference)

Synonyms	Catechuic acid, (+)-Catechin, Cianidanol, D-Catechin, Catechinic acid
Molecular Weight	290.27
Formula	C15H14O6
CAS No.	154-23-4

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 54 mg/mL (186 mM)

H2O: 53 mg/mL (182.6 mM)

Ethanol: 54 mg/mL (186 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Daniela Laura Papademetrio, et al. Rev bras farmacogn. 2013, 23(3):455-463. 2. Tayyaba Afsar, et al. Scientific Reports 6. 2016, 23077. 3. Noreen Y, et al. Planta Med. 1998, 64(6):520-4. 4. Yin P, et al. Cancer Lett. 1994, 79(1):33-8. 5. Ebeler SE, et al. Am J Clin Nutr. 2002, 76(4):865-72. 6. Hwang Y H, Jang S A, Kim T, et al. Anti-osteoporotic and Anti-adipogenic Effects of Rhus chinensis Nutgalls in Ovariectomized Mice Fed with a High-fat Diet[J]. Planta medica. 2019. 7. Jang S A, Hwang Y H, Kim T, et al. Anti-Osteoporotic and Anti-Adipogenic Effects of the Water Extract of Drynaria roosii Nakaike in Ovariectomized Mice Fed a High-Fat Diet[J]. Molecules. 2019, 24(17): 3051. 8. Shim K S, Hwang Y H, Jang S A, et al. . Water Extract of Lysimachia christinae Inhibits Trabecular Bone Loss and Fat Accumulation in Ovariectomized Mice[J]. Nutrients. 2020, 12(7): 1927.

Citations

1. Shim K S, Hwang Y H, Jang S A, et al. Water Extract of Lysimachia christinae Inhibits Trabecular Bone Loss and Fat Accumulation in Ovariectomized Mice. Nutrients. 2020, 12(7): 1927 2. Jang S A, Hwang Y H, Kim T, et al. Anti-Osteoporotic and Anti-Adipogenic Effects of the Water Extract of Drynaria roosii Nakaike in Ovariectomized Mice Fed a High-Fat Diet. Molecules. 2019, 24(17): 3051 3. Hwang Y H, Jang S A, Kim T, et al. Anti-osteoporotic and Anti-adipogenic Effects of Rhus chinensis Nutgalls in Ovariectomized Mice Fed with a High-fat Diet. Planta Medica. 2019, 85(14/15): 1128-1135

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Catechin 154-23-4 Apoptosis Immunology/Inflammation Metabolism Microbiology/Virology Neuroscience Influenza Virus COX Endogenous Metabolite Catechuic acid inhibit (+)-Catechin Cianidanol D-Catechin Catechinic acid Cyclooxygenase Inhibitor inhibitor

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