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CZC24832

Catalog No. T1949 CAS 1159824-67-5

CZC24832 is a selective inhibitor of PI 3-kinase γ.

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CZC24832, CAS 1159824-67-5

Pack Size	Availability	Price/USD
1 mg	In stock	$ 43.00
2 mg	In stock	$ 61.00
5 mg	In stock	$ 98.00
10 mg	In stock	$ 148.00
25 mg	In stock	$ 252.00
50 mg	In stock	$ 375.00
100 mg	In stock	$ 553.00
1 mL * 10 mM (in DMSO)	In stock	$ 112.00

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Purity: 99.45%

Purity: 99.12%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	CZC24832 is a selective inhibitor of PI 3-kinase γ.
Targets&IC50	PI3Kγ:27 nM, PI3Kβ:1.1 μM
In vitro	In a therapeutic model of collagen-induced arthritis (CIA), mice administered 10 mg/kg of CZC24832 orally twice daily exhibited significant reductions in both bone and cartilage destruction and overall clinical parameters. Additionally, in an IL-8-dependent air-pouch model, CZC24832 demonstrated a dose-dependent decrease in granulocyte recruitment, consistent with the level of inhibition observed in mice lacking PI3Kγ.
In vivo	In the BT system, treatment with CZC24832 significantly inhibits IL-17A (IC50 = 1.5 μM) as well as B-cell activation markers, such as IL-6 and IgG. Moreover, in T-cell systems, such as in human umbilical vein endothelial cells, the production of IL17A is strongly suppressed, indicating that PI3Kγ kinase activity plays a broad role in the functionality of TH17 cells. Accordingly, CZC24832 inhibits the differentiation of TH17 cells. A high-throughput screening of 154 lipid and protein kinases, alongside 922 other proteins, identified only PI3Kβ and PIP4K2C as off-target proteins within a 100-fold selectivity window.
Kinase Assay	AZD4547 kinase activity: The ability of AZD4547 to inhibit the human recombinant kinase activities of FGFR1-3 is tested using ATP concentrations at, or just below, the respective Km.

Molecular Weight	364.4
Formula	C15H17FN6O2S
CAS No.	1159824-67-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 36.4 mg/mL (100 mM)

References and Literature

1. Bergamini G, et al. Nat Chem Biol, 2012, 8(6), 576-582.

Citations

1. Huang Q, Ru Y, Luo Y, et al.Identification of a targeted ACSL4 inhibitor to treat ferroptosis-related diseases.Science Advances.2024, 10(13): eadk1200.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Kinase Inhibitor Library Stem Cell Differentiation Compound Library Immunology/Inflammation Compound Library Anti-Liver Cancer Compound Library Anti-Ovarian Cancer Compound Library Immuno-Oncology Compound Library Fluorochemical Library Anti-Cancer Compound Library Anti-Lung Cancer Compound Library

Related Products

Related compounds with same targets

PI4KIIIbeta-IN-9 CC-115 CXJ-2 YS-49 PI3Kα/mTOR-IN-1 AS-604850 IITZ-01 Dactolisib

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Keywords

CZC24832 1159824-67-5 PI3K/Akt/mTOR signaling PI3K Phosphoinositide 3-kinase Inhibitor inhibit CZC 24832 CZC-24832 inhibitor

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