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CL 316243

Catalog No. T10830 CAS 138908-40-4

CL316243 is a highly potent selective agonist of β3-adrenoceptor, with a EC50 of 3 nM. CL316243 is an effective stimulant of adipocyte lipolysis and increases brown adipose tissue thermogenesis and metabolic rate. CL316243 has the potential for the treatment obesity, diabetes and urge urinary incontinence.

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CL 316243, CAS 138908-40-4

Pack Size	Availability	Price/USD
1 mg	In stock	$ 48.00
5 mg	In stock	$ 113.00
10 mg	In stock	$ 172.00
25 mg	In stock	$ 347.00
50 mg	In stock	$ 555.00
100 mg	In stock	$ 888.00
500 mg	In stock	$ 1,770.00

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Purity: 99.68%

ee: 100%

Purity: 99.34%

ee: 100%

Purity: 98.00%

Biological Description

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Storage & Solubility Information

Description	CL316243 is a highly potent selective agonist of β3-adrenoceptor, with a EC50 of 3 nM. CL316243 is an effective stimulant of adipocyte lipolysis and increases brown adipose tissue thermogenesis and metabolic rate. CL316243 has the potential for the treatment obesity, diabetes and urge urinary incontinence.
Targets&IC50	β3-adrenoceptor:(EC50)3 nM
In vitro	CL 316243 displays binding affinities with IC50 values of 1 μM and 0.6 μM for rat soleus muscle and rat heart respectively. CL 316243 inhibits spontaneously contracting, isolated rat detrusor strips in a concentration-dependent manner with a mean concentration inhibiting 50% of the maximal response of 2.65 nM [1].
In vivo	CL316243 disodium (subcutaneously injection; 0.1 mg/kg/day; once a day; 1 week) elevates the mRNA and protein expression levels of BAT in UCP1 [2].

Molecular Weight	465.79
Formula	C20H18ClNNa2O7
CAS No.	138908-40-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 80 mg/mL (171.75 mM), Sonication is recommended.

References and Literature

1. Bloom JD, et al. Disodium (R,R)-5-[2-[[2-(3-chlorophenyl)-2-hydroxyethyl]-amino] propyl]-1,3-benzodioxole-2,2-dicarboxylate (CL 316,243). A potent beta-adrenergic agonist virtually specific for beta 3 receptors. A promising antidiabetic and antiobesity agent.J Med Chem. 1992 Aug 7;35(16):3081-4. 2. Shin W, et al. Impaired adrenergic agonist-dependent beige adipocyte induction in obese mice.J Vet Med Sci. 2019 Jun 6;81(6):799-807.

Related compound libraries

This product is contained In the following compound libraries：

GPCR Compound Library Membrane Protein-targeted Compound Library Anti-Cancer Compound Library Bioactive Compounds Library Max Anti-Obesity Compound Library Bioactive Compound Library Neuronal Signaling Compound Library

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Keywords

CL 316243 138908-40-4 GPCR/G Protein Neuroscience Adrenergic Receptor inhibit Inhibitor Beta Receptor CL-316243 CL316243 inhibitor

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