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CHF5074

Catalog No. T2262 CAS 749269-83-8

Synonyms: CSP-1103, Itanapraced

CHF5074, a γ-secretase modulator, reduces Aβ42/40 secretion (IC50: 3.6/18.4 μM).

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

CHF5074, CAS 749269-83-8

Pack Size	Availability	Price/USD
2 mg	In stock	70.00
5 mg	In stock	97.00
10 mg	In stock	139.00
50 mg	In stock	450.00
100 mg	In stock	652.00
1 mL * 10 mM (in DMSO)	In stock	97.00

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Purity 99.79%

HNMR HPLC COA

Purity 98.00%

HNMR COA

Datasheet SDS

Biological Description

Chemical Properties

Storage & Solubility Information

Description	CHF5074, a γ-secretase modulator, reduces Aβ42/40 secretion (IC50: 3.6/18.4 μM).
Targets&IC50	Beta Amyloid , γ secretase

Synonyms	CSP-1103 , Itanapraced
Purity	99.79%
Molecular Weight	325.16
Formula	C16H11Cl2FO2
CAS No.	749269-83-8

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 6 months

Solubility Information

DMSO: 37 mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature

1. Imbimbo BP, et al. J Pharmacol Exp Ther. 2007 Dec;323(3):822-30. 2. Ronsisvalle N, et al. Curr Alzheimer Res. 2014;11(7):714-24.

Related compound libraries

This product is contained In the following compound libraries：

Bioactive Compound Library Inhibitor Library Anti-Cancer Compound Library Clinical Compound Library Stem Cell Differentiation Compound Library Neuronal Signaling Compound Library Anti-Cancer Clinical Compound Library Preclinical Compound Library Anti-Aging Compound Library Anti-Cancer Drug Library Drug Repurposing Compound Library Anti-Neurodegenerative Disease Compound Library Anti-Parkinson's Disease Compound Library Anti-Alzheimer's Disease Compound Library

Related Products

Related compounds with same targets

MDR-1339 β-amyloid 1-11 acetate(190436-05-6 free base) Colivelin Amyloid β-Protein 10-20 acetate Jagged-1 （188-204） Jagged-1 (188-204) TFA(219127-21-6 free base) β-Amyloid 15-21 acetate Amyloid β-Peptide (1-42) human

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.