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Bicyclomycin benzoate

Catalog No. T10541   CAS 37134-40-0
Synonyms: FR2054

Bicyclomycin benzoate, an antibiotic, exhibits activity against a broad spectrum of Gram-negative/Gram-positive bacteria.

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Bicyclomycin benzoate Chemical Structure
Bicyclomycin benzoate, CAS 37134-40-0
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Bicyclomycin benzoate, an antibiotic, exhibits activity against a broad spectrum of Gram-negative/Gram-positive bacteria.
In vitro Bicyclomycin interferes with the biosynthesis of lipoprotein and its assembly to peptidoglycan in the cell envelope of E. coli. At the lethal level, Bicyclomycin is shown to inhibit the synthesis of RNA and protein in the growing cells of E. coli 15 THU [1]. Bicyclomycin targets the rho transcription termination factor in Escherichia coli. Bicyclomycin can disrupt the rho molecular machinery thereby leading to a catastrophic effect caused by the untimely overproduction of proteins not normally expressed constitutively, thus leading to a toxic effect on the cells [2]. The inhibition of rho poly(C)-stimulated hydrolysis of ATP by Bicyclomycin has been found to proceed by a non-competitive, reversible pathway with respect to ATP (Ki: 20 μM) [3].
In vivo After a single intramuscular dose of 50 mg/kg in rats, Bicyclomycin has a low excretion rate. Bicyclomycin is well distributed in various tissues, and the highest concentration is observed in the kidney at 100 mg/kg [4].
Synonyms FR2054
Molecular Weight 406.39
Formula C19H22N2O8
CAS No. 37134-40-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (246.07 mM), sonification is recommended.

TargetMolReferences and Literature

1. Tanaka N, et al. Mechanism of action of bicyclomycin. J Antibiot (Tokyo). 1976 Feb;29(2):155-68. 2. Kohn H, et al. The molecular basis for the mode of action of bicyclomycin. Curr Drug Targets Infect Disord. 2005 Sep;5(3):273-95. 3. Park HG, et al. Bicyclomycin and dihydrobicyclomycin inhibition kinetics of Escherichia coli rho-dependent transcription termination factor ATPase activity. Arch Biochem Biophys. 1995 Nov 10;323(2):447-54. 4. Nishida M. et al. Bicyclomycin, a new antibiotic. IV. Absorption, excretion and tissue distribution. J Antibiot (Tokyo). 1972 Oct;25(10):594-601.

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Keywords

Bicyclomycin benzoate 37134-40-0 Others FR 2054 FR2054 Bicyclomycin Benzoate FR-2054 inhibitor inhibit

 

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