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Bepridil free base

Catalog No. T5391L CAS 64706-54-3

Synonyms: CERM1978, CERM 1978, Bepadin, CERM-1978, Angopril

Bepridil is a class IV anti-arrhythmic agent and calcium antagonist. Bepridil hydrochloride blocks calcium entry through membranous calcium channels of coronary and peripheral vascular smooth muscle, thereby dilating coronary arteries and peripheral arterioles.

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Bepridil free base, CAS 64706-54-3

Pack Size	Availability	Price/USD
25 mg	6-8 weeks	$ 1,520.00
50 mg	6-8 weeks	$ 1,980.00
100 mg	6-8 weeks	$ 2,500.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	CERM1978, CERM 1978, Bepadin, CERM-1978, Angopril
Molecular Weight	366.54
Formula	C24H34N2O
CAS No.	64706-54-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Ren J, Zhao Y, Fry EE, Stuart DI. Target identification and mode of action of four chemically divergent drugs against Ebola virus infection. J Med Chem. 2017 Dec 22. doi: 10.1021/acs.jmedchem.7b01249. [Epub ahead of print] PubMed PMID: 29272110. 2. Aprahamian ML, Tikunova SB, Price MV, Cuesta AF, Davis JP, Lindert S. Successful Identification of Cardiac Troponin Calcium Sensitizers Using a Combination of Virtual Screening and ROC Analysis of Known Troponin C Binders. J Chem Inf Model. 2017 Dec 26;57(12):3056-3069. doi: 10.1021/acs.jcim.7b00536. Epub 2017 Nov 16. PubMed PMID: 29144742; PubMed Central PMCID: PMC5743627. 3. Abbate E, Boulakia M, Coudière Y, Gerbeau JF, Zitoun P, Zemzemi N. In silico assessment of the effects of various compounds in MEA/hiPSC-CM assays: Modeling and numerical simulations. J Pharmacol Toxicol Methods. 2018 Jan - Feb;89:59-72. doi: 10.1016/j.vascn.2017.10.005. Epub 2017 Oct 21. PubMed PMID: 29066291. 4. Sheng J, Tran PN, Li Z, Dutta S, Chang K, Colatsky T, Wu WW. Characterization of loperamide-mediated block of hERG channels at physiological temperature and its proarrhythmia propensity. J Pharmacol Toxicol Methods. 2017 Nov - Dec;88(Pt 2):109-122. doi: 10.1016/j.vascn.2017.08.006. Epub 2017 Aug 19. PubMed PMID: 28830713.

Dose Conversion

You can also refer to dose conversion for different animals. More

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
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The answer of 19.713 mg appears in the Mass box

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Calculator the dilution required to prepare a stock solution

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The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
Enter 10 into the Concentration (start) box and select the correct unit (millimolar)
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The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

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Molecule Formula

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Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Bepridil free base 64706-54-3 CERM1978 CERM 1978 Bepadin CERM-1978 Angopril Bepridil inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.