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Endocrinology/Hormones Glucocorticoid Receptor Beclomethasone dipropionate

Beclomethasone dipropionate

Catalog No. T1127   CAS 5534-09-8
Synonyms: Beclometasone dipropionate, Beconase, Beclovent, Vancenase

Beclomethasone Dipropionate is the dipropionate ester of a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. After cell surface receptor attachment and cell entry, beclomethasone enters the nucleus where it binds to and activates specific nuclear receptors, resulting in an altered gene expression and inhibition of proinflammatory cytokine production.

Beclomethasone dipropionate, CAS 5534-09-8
Pack Size Availability Price/USD Quantity
5 mg In stock 25.00
25 mg In stock 37.00
100 mg In stock 46.00
200 mg In stock 57.00
1 mL * 10 mM (in DMSO) In stock 37.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Beclomethasone Dipropionate is the dipropionate ester of a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. After cell surface receptor attachment and cell entry, beclomethasone enters the nucleus where it binds to and activates specific nuclear receptors, resulting in an altered gene expression and inhibition of proinflammatory cytokine production.
Targets&IC50 Glucocorticoid Receptor,  
In vitro Beclomethasone dipropionate (BDP) is an anti-inflammatory corticosteroid available for the treatment of asthma and allergic rhinitis (AR). BDP is previously developed as aqueous nasal formulations for the treatment of AR. BDP is also available in dry nasal aerosol formulations as chlorofluoro carbon (CFC) metered-dose inhaler nasal sprays, but CFC-containing formulations have been withdrawn from the market and currently are not available.BDP hydrofluoroalkane (HFA) inhalation aerosol currently is available for patient use and indicated for the maintenance treatment of asthma as prophylactic therapy in patients 5 years of age and older.BDP HFA nasal aerosol, an intranasal aerosol formulation, has been developed recently for the treatment of AR.
Synonyms Beclometasone dipropionate , Beconase , Beclovent , Vancenase
Purity 99.44%
Molecular Weight 521.04
Formula C28H37ClO7
CAS No. 5534-09-8

Storage

0-4℃ for short term (days to weeks), or -20℃ for long term (months).

Solubility Information

DMSO: 10 mM

Ethanol: 18 mg/mL (34.55 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Ratner PH, et al. Clin Ther, 2012, 34(6), 1422-1431. 2. Busse WW, et al. J Allergy Clin Immunol, 1999, 104(6), 1215-1222.

Related compound libraries

This product is contained In the following compound libraries:
Approved Drug Library Bioactive Compound Library Inhibitor Library Endocrinology-Hormones Library FDA-approved Drug Library GPCR Compound Library Anti-Metabolism Disease Compound Library

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Dexamethasone BecloMethasone Finerenone Glucagon hydrochloride (16941-32-5 free base) GW-870086 AZD7594 Esaxerenone Relacorilant

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