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BBIQ

Catalog No. T14513 CAS 1229024-57-0

BBIQ is a powerful vaccine adjuvant that enhances innate immune responses and a potent and selectively toll-like receptor 7 (TLR7) agonist with an EC50 of  59.1 nM for human TLR7.

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BBIQ, CAS 1229024-57-0

Pack Size	Availability	Price/USD
5 mg	In stock	$ 39.00
10 mg	In stock	$ 57.00
25 mg	In stock	$ 90.00
50 mg	In stock	$ 132.00
1 mL * 10 mM (in DMSO)	In stock	$ 54.00

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Purity: 98.02%

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Description	BBIQ is a powerful vaccine adjuvant that enhances innate immune responses and a potent and selectively toll-like receptor 7 (TLR7) agonist with an EC50 of  59.1 nM for human TLR7.
Targets&IC50	TLR7:59.1 nM （EC50）（ Human TLR7)
In vitro	BBIQ induces IFN-α in human PBMCs (520 pg/mL at 5 µg/mL)[1].
In vivo	In an experimental study, mice that received only Chloroquine (CQ) for treatment showed signs of the parasite (P. berghei ANKA) by Day 17 and succumbed by Day 21. Conversely, those administered a combination of BBIQ and CQ did not exhibit any parasitic presence up to Day 23. Additionally, the combined treatment with BBIQ + CQ resulted in a reduction of T cell frequencies (CD3+, CD4+, and CD8+) and T regulatory cell frequencies (CD4+, CD25+, and FoxP3+) in the brain when compared to the effects of BBIQ or CQ alone on Day 10. This treatment also elevated the serum levels of IFN-γ and IL-12, indicating a strong Th1 immune response against the infection on the same day. The study suggests that the BBIQ + CQ combination therapy not only inhibits the infiltration of inflammatory T cells but also activates T helper and T cytotoxic cells to combat the parasite effectively.

Molecular Weight	330.43
Formula	C21H22N4
CAS No.	1229024-57-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 3.3 mg/mL (10 mM), Sonification is recommended

References and Literature

1. Saroa R, et al. Efficacy of TLR7 agonistic imidazoquinoline as immunochemotherapeutic agent against P. Berghei ANKA infected rodent host. Bioorg Med Chem Lett. 2019 May 1;29(9):1099-1105. 2. Kaushik D, et al. BBIQ, a pure TLR7 agonist, is an effective influenza vaccine adjuvant. Hum Vaccin Immunother. 2020 Apr 16:1-8.

Related compound libraries

This product is contained In the following compound libraries：

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

BBIQ 1229024-57-0 Immunology/Inflammation TLR inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.