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Home > Neuroscience > Gamma-secretase > Avagacestat

Avagacestat

Catalog No. T6249    CAS 1146699-66-2    Synonyms: BMS-708163

Avagacestat (BMS-708163) is a potent, selective, orally bioavailable γ-secretase inhibitor of Aβ40 and Aβ42 with IC50 of 0.3 nM and 0.27 nM, demonstrating a 193-fold selectivity against Notch. Phase 2.

Pack Size Availability Price/USD Quantity
2 mg In stock 75.00
5 mg In stock 114.00
10 mg In stock 218.00
25 mg In stock 343.00
50 mg In stock 675.00
1 mL * 10 mM (in DMSO) In stock 170.00
Bulk Size: Please Quote for Discount Please Quote for Bulk Size
Biological Activity:

Product Description:

Avagacestat (BMS-708163) is a potent, selective, orally bioavailable γ-secretase inhibitor of Aβ40 and Aβ42 with IC50 of 0.3 nM and 0.27 nM, demonstrating a 193-fold selectivity against Notch. Phase 2.

Receptor:

γ secretase(Aβ40); γ secretase(Aβ42);

Chemical Information:
Molecular Weight 520.88
Formula C20H17ClF4N4O4S
CAS Number 1146699-66-2
Solubility

DMSO: 96 mg/mL (184.3 mM)

Ethanol: <1 mg/mL

Water: <1 mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )
Storage store at -80°C
Remark For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ℃ for several month.
Technical Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store Products, and issues that need special attention for cell-based assays and animal experiments.

Reference
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