Catalog No. T6249 CAS 1146699-66-2 Synonyms: BMS-708163
Avagacestat (BMS-708163) is a potent, selective, orally bioavailable γ-secretase inhibitor of Aβ40 and Aβ42 with IC50 of 0.3 nM and 0.27 nM, demonstrating a 193-fold selectivity against Notch. Phase 2.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | In stock | 75.00 |
|
5 mg | In stock | 114.00 |
|
10 mg | In stock | 218.00 |
|
25 mg | In stock | 343.00 |
|
50 mg | In stock | 675.00 |
|
1 mL * 10 mM (in DMSO) | In stock | 170.00 |
|
Product Description: Avagacestat (BMS-708163) is a potent, selective, orally bioavailable γ-secretase inhibitor of Aβ40 and Aβ42 with IC50 of 0.3 nM and 0.27 nM, demonstrating a 193-fold selectivity against Notch. Phase 2. |
Receptor: γ secretase(Aβ40); γ secretase(Aβ42); |
Molecular Weight | 520.88 |
Formula | C20H17ClF4N4O4S |
CAS Number | 1146699-66-2 |
Solubility |
DMSO: 96 mg/mL (184.3 mM) Ethanol: <1 mg/mL Water: <1 mg/mL ( < 1 mg/ml refers to the product slightly soluble or insoluble ) |
Storage | store at -80°C |
Remark | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ℃ for several month. |
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store Products, and issues that need special attention for cell-based assays and animal experiments.