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Avagacestat

Catalog No. T6249 CAS 1146699-66-2 Synonyms: BMS-708163

Avagacestat (BMS-708163) is a potent, selective, orally bioavailable γ-secretase inhibitor of Aβ40 and Aβ42 with IC50 of 0.3 nM and 0.27 nM, demonstrating a 193-fold selectivity against Notch. Phase 2.

Purity 98.0% COA Datasheet

Pack Size	Availability	Price/USD
2 mg	In stock	75.00
5 mg	In stock	114.00
10 mg	In stock	218.00
25 mg	In stock	343.00
50 mg	In stock	675.00
1 mL * 10 mM (in DMSO)	In stock	170.00

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Biological Activity:

Product Description:

Receptor:

γ secretase(Aβ40); γ secretase(Aβ42);

Chemical Information:

Molecular Weight	520.88
Formula	C20H17ClF4N4O4S
CAS Number	1146699-66-2
Solubility	DMSO: 96 mg/mL (184.3 mM) Ethanol: <1 mg/mL Water: <1 mg/mL ( < 1 mg/ml refers to the product slightly soluble or insoluble )
Storage	store at -80°C
Remark	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ℃ for several month.

Technical Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store Products, and issues that need special attention for cell-based assays and animal experiments.

Reference

1. Gillman KW, et al. Med Chem Lett, 2010, 1 (3), 120–124.

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