keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Arenobufagin is a natural bufadienolide from toad venom with potent antineoplastic activity against HCC HepG2 cells and corresponding multidrug-resistant HepG2/ADM cells.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 67.00 | |
5 mg | In stock | $ 145.00 | |
10 mg | In stock | $ 278.00 | |
25 mg | In stock | $ 469.00 | |
50 mg | In stock | $ 677.00 | |
100 mg | In stock | $ 943.00 | |
500 mg | In stock | $ 1,880.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 159.00 |
Description | Arenobufagin is a natural bufadienolide from toad venom with potent antineoplastic activity against HCC HepG2 cells and corresponding multidrug-resistant HepG2/ADM cells. |
In vitro | Arenobufagin induced mitochondria-mediated apoptosis in HCC cells, with decreasing mitochondrial potential, as well as increasing Bax/Bcl-2 expression ratio, Bax translocation from cytosol to mitochondria. Arenobufagin also induced autophagy in HepG2/ADM cells. Autophagy-specific inhibitors (3-methyladenine, chloroquine and bafilomycin A1) or Beclin1 and Atg 5 small interfering RNAs (siRNAs) enhanced arenobufagin-induced apoptosis, indicating that arenobufagin-mediated autophagy may protect HepG2/ADM cells from undergoing apoptotic cell death [1]. arenobufagin inhibited vascular endothelial growth factor (VEGF)-induced viability, migration, invasion and tube formation in human umbilical vein endothelial cells (HUVECs) in vitro [2]. Arenobufagin blocked the Na+/K+ pump current in a dose-dependent manner with a half-maximal concentration of 0.29 microM and a Hill coefficient of 1.1 [3]. |
In vivo | Arenobufagin inhibited the growth of HepG2/ADM xenograft tumors, which were associated with poly (ADP-ribose) polymerase cleavage, light chain 3-II activation and mTOR inhibition [1]. Arenobufagin also suppressed sprouting formation from VEGF-treated aortic rings in an ex vivo model [2]. |
Molecular Weight | 416.51 |
Formula | C24H32O6 |
CAS No. | 464-74-4 |
keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 83 mg/mL (199.27 mM ), Sonication is recommended.
Ethanol: 10 mg/mL (24.1 mM)
You can also refer to dose conversion for different animals. More
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Arenobufagin 464-74-4 Others inhibit Inhibitor inhibitor