Home Tools

Cart

Ammonium Glycyrrhizinate

Catalog No. T6384 CAS 1407-03-0

Synonyms: Glycyram, Glycamil, AMGZ

Ammonium Glycyrrhizinate (Glycyram) inhibits the cytopathology and growth of several unrelated DNA/RNA viruses.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Ammonium Glycyrrhizinate Chemical Structure

Ammonium Glycyrrhizinate, CAS 1407-03-0

Pack Size	Availability	Price/USD	Quantity
100 mg	In stock	$ 29.00
1 mL * 10 mM (in DMSO)	In stock	$ 46.00

Bulk Inquiry

Select Batch

Purity: 98.05%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Ammonium Glycyrrhizinate (Glycyram) inhibits the cytopathology and growth of several unrelated DNA/RNA viruses.
In vitro	Ammonium glycyrrhizinate (AG) markedly protects AGS cells from H(2)O(2)-induced damage as measured by the integrity of actin cytoskeleton. AG also dose-dependently inhibits FeSO(4)-induced reactive oxygen radicals.
In vivo	Ammonium glycyrrhizinate down-regulates the TNF-α level and up-regulates IL-10 level and inhibits the cAMP-PDE activity in the lung tissue of mice. Ammonium glycyrrhizinate (28 mg/kg) leads to changes in the activity of some enzymes in the brain, the development of parenchymatous dystrophy of the liver which changed to acidophilic necrosis attended with signs of regeneration in mice and rats model. Ammonium glycyrrhizinate -loaded non-ionic surfactant vesicles shows no toxicity, good skin tolerability and are able to improve the drug anti-inflammatory activity in mice. Ammonium glycyrrhizinate increases HDL levels in rats. Ammonium glycyrrhizinate significantly decreases cholesterol, triglyceride, LDL and very VLDL levels in rats.

Synonyms	Glycyram, Glycamil, AMGZ
Molecular Weight	839.96
Formula	C42H62O16·NH3
CAS No.	1407-03-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 155 mg/mL (184.5 mM)

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

H2O: 5 mg/mL (5.95 mM)

References and Literature

1. Oh HM, et al. Exp Biol Med (Maywood), 2009, 234(3), 263-277. 2. Antov G, et al. Eksp Klin Farmakol, 1997, 60(2), 65-67. 3. Marianecci C, et al. Int J Nanomedicine, 2014, 9, 635-651. 4. Marianecci C, et al. J Control Release, 2012, 164(1), 17-25. 5. Garg M, et al. Indian J Pharmacol, 2014, 46(5), 527-530. 6. Li C, et al. Glycyrrhizin, a Direct HMGB1 Antagonist, Ameliorates Inflammatory Infiltration in a Model of Autoimmune Thyroiditis via Inhibition of TLR2-HMGB1 Signaling. Thyroid. 2017 May;27(5):722-731. 7. Su X, et al. Glycyrrhizic acid: A promising carrier material for anticancer therapy. Biomed Pharmacother. 2017 Nov;95:670-678.

Related compound libraries

This product is contained In the following compound libraries：

Natural Product Library for HTS Traditional Chinese Medicine Monomer Library Anti-Tumor Natural Product Library Anti-Infection Compound Library Traditional Mongolian Medicine Compound Library Anti-COVID-19 Compound Library Anti-COVID-19 Traditional Chinese Medicine Compound Library Anti-virus Traditional Chinese Medicine Monomer Library Covalent Natural Product Library Approved Drug Library

Related Products

Related compounds with same targets

(R)-GNE-140 18β-Glycyrrhetinic acid 4-Hydroxynonenal Galloflavin Methotrexate disodium LW6 6''-O-Acetylglycitin XEN723

Dose Conversion

You can also refer to dose conversion for different animals. More

In vivo Formulation Calculator (Clear solution)

Step One: Enter information below

Dosage

mg/kg

Average weight of animals

Dosing volume per animal

Number of animals

Step Two: Enter the in vivo formulation

% DMSO+

% +

% Tween 80+

% ddH₂O

%DMSO+

Calculate Reset

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

Calculator

Molarity Calculator

Dilution Calculator

Reconstitution Calculation

Molecular Weight Calculator

Mass

Concentration

Volume

Molecular Weight

Molarity Calculator allows you to calculate the

Mass of a compound required to prepare a solution of known volume and concentration
Volume of solution required to dissolve a compound of known mass to a desired concentration
Concentration of a solution resulting from a known mass of compound in a specific volume

See Example

An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
Enter 10 into the Concentration box and select the correct unit (millimolar)
Enter 10 into the Volume box and select the correct unit (milliliter)
Press calculate
The answer of 19.713 mg appears in the Mass box

Concentration (Start)

Volume (Start)

Concentration (End)

Volume (End)

Calculator the dilution required to prepare a stock solution

Calculate the dilution required to prepare a stock solution
The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

See Example

An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
Enter 10 into the Concentration (start) box and select the correct unit (millimolar)
Enter 50 into the Concentration (final) box and select the correct unit (micromolar)
Enter 20 into the Volume (final) box and select the correct unit (milliliter)
Press calculate
The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

Calculate the volume of solvent required to reconstitute your vial.

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial.
Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Molecule Formula

Molecular Weight g/mol

Enter the chemical formula of a compound to calculate its molar mass and elemental composition

Tip: Chemical formula is case sensitive: C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:
To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.
Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

bottom

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Ammonium Glycyrrhizinate 1407-03-0 Metabolism Dehydrogenase Glycyram Glycamil AMGZ inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.