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ALSTERPAULLONE

Catalog No. T7426   CAS 237430-03-4

Alsterpaullone is a Cyclin-Dependent Kinase Inhibitor, Mediated Toxicity in HeLa Cells Through Apoptosis-Inducing Effec

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ALSTERPAULLONE Chemical Structure
ALSTERPAULLONE, CAS 237430-03-4
Pack Size Availability Price/USD Quantity
1 mg In stock $ 97.00
5 mg In stock $ 213.00
10 mg In stock $ 343.00
25 mg In stock $ 583.00
50 mg In stock $ 835.00
100 mg In stock $ 1,150.00
1 mL * 10 mM (in DMSO) In stock $ 198.00
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Purity: 99.39%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Alsterpaullone is a Cyclin-Dependent Kinase Inhibitor, Mediated Toxicity in HeLa Cells Through Apoptosis-Inducing Effec
Targets&IC50 CDK5/p35:40 nM, cdk2/cyclin A:15 nMCD, K2/Cyc E:200 nM, Cdk1/cyclin B:35 nM
In vitro Alsterpaullone inhibited HeLa cells in a time-dependent (0-72 h) and dose-dependent (0-30 μ M) manner.?In the presence of alsterpaullone, HeLa cells were arrested in G2/M prior to undergoing apoptosis via a mechanism that is involved in the regulation of various antiapoptotic genes, DNA-repair, transcription, and cell cycle progression.?Compared to controls, alsterpaullone effectively prevented HeLa cells from entering S-phase.?These potential therapeutic efficacies could be correlated with the activation of caspase-3[1].
Molecular Weight 293.28
Formula C16H11N3O3
CAS No. 237430-03-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 12 mg/mL (40.92 mM)

TargetMolReferences and Literature

1. Cui C , Wang Y , Wang Y , et al. Alsterpaullone, a Cyclin-Dependent Kinase Inhibitor, Mediated Toxicity in HeLa Cells through Apoptosis-Inducing Effect[J]. Journal of Analytical Methods in Chemistry, 2013, 2013:1-5. 2. Faria C C , Agnihotri S , Mack S C , et al. Identification of alsterpaullone as a novel small molecule inhibitor to target group 3 medulloblastoma[J]. Oncotarget, 2015, 6(25):21718-21729.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Active Compound Library Kinase Inhibitor Library Bioactive Compound Library NO PAINS Compound Library Anti-Lung Cancer Compound Library Anti-Liver Cancer Compound Library Glycolysis Compound Library Wnt/Hedgehog/Notch Compound Library Cell Cycle Compound Library Stem Cell Differentiation Compound Library

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Keywords

ALSTERPAULLONE 237430-03-4 Apoptosis Cell Cycle/Checkpoint PI3K/Akt/mTOR signaling Stem Cells GSK-3 CDK CDK5 p35 NSC-705701 9-Nitropaullone NSC705701 Glycogen synthase kinase-3 cyclin E Glycogen synthase kinase 3 Cyclin dependent kinase inhibit NSC 705701 antitumor CDK2 cyclin A cyclin B Inhibitor CDK1 neurodegenerative inhibitor

 

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