Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Alkannin is a potent and specific tumor-specific pyruvate kinase-M2 (PKM2) inhibitor that does not inhibit PKM1 and pyruvate kinase-L (PKL). Alkannin is a potential anticancer agent [1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 10-14 weeks | $ 1,520.00 | |
50 mg | 10-14 weeks | $ 1,980.00 | |
100 mg | 10-14 weeks | $ 2,500.00 |
Description | Alkannin is a potent and specific tumor-specific pyruvate kinase-M2 (PKM2) inhibitor that does not inhibit PKM1 and pyruvate kinase-L (PKL). Alkannin is a potential anticancer agent [1]. |
In vitro | Alkannin is a potent and specific inhibitor of PKM2, a critical enzyme in the final rate-limiting step of glycolysis, pivotal for the proliferation and survival of cancer cells. The IC50 values of Alkannin are 0.3 μM in the absence of D-fructose-1,6-bisphosphate (FBP) and 0.9 μM in its presence at 125 μM, demonstrating a concentration-dependent inhibition of cellular glycolytic flux in cancer cells predominantly expressing PKM2. Moreover, Alkannin treatment (2.5-20 μM for 1 hour) reduces both lactate production and glucose consumption rate in these cells [1]. Western Blot Analysis confirms that Alkannin, within a concentration range of 0-20 μM over an incubation period of 1 hour, significantly inhibits the glycolytic rate in a concentration-dependent manner in MCF-7 and A549 cell lines, which express PKM2 but not PKM1 and PKL [1]. |
Molecular Weight | 288.3 |
Formula | C16H16O5 |
CAS No. | 23444-65-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Alkannin 23444-65-7 inhibitor inhibit