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Ac-YVAD-CHO

Name: Ac-YVAD-CHO
Brand: TargetMol
SKU: T19883
Price: 73 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T19883Cas No. 143313-51-3

Alias L-709049, L709049, L 709049

Ac-YVAD-CHO (L 709049) is a selective and potent tetrapeptide interleukin 1β-converting enzyme (ICE) and caspase-1 (ICE)-like protease inhibitor with anti-inflammatory activity, inhibits cancer cell growth, and inhibits the production of mature IL-lβ. Ac-YVAD-CHO attenuates quinolinic acid-induced p53 increase and apoptosis in rat striatum.

Ac-YVAD-CHO

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Purity: 96.49%

Catalog No. T19883Alias L-709049, L709049, L 709049Cas No. 143313-51-3

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$73	In Stock	In Stock
5 mg	$289	In Stock	In Stock
10 mg	$428	-	In Stock
25 mg	$698	-	In Stock
50 mg	$968	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:96.49%

Appearance:Solid

Color:White

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COA HPLC MS

Product Introduction

Bioactivity

Description	Ac-YVAD-CHO (L 709049) is a selective and potent tetrapeptide interleukin 1β-converting enzyme (ICE) and caspase-1 (ICE)-like protease inhibitor with anti-inflammatory activity, inhibits cancer cell growth, and inhibits the production of mature IL-lβ. Ac-YVAD-CHO attenuates quinolinic acid-induced p53 increase and apoptosis in rat striatum.
Targets&IC50	IL-1β (human):0.7 μM, IL-1β (mouse):2.5 μM
In vitro	Ac-YVAD-CHO reduced the elevation of IL-1β in LPS-treated plasma and peritoneal fluid.Ac-YVAD-CHO inhibited IL-1β with IC50=2.5 μM (mouse) and IC50=0.7 μM (human) in both mouse and human. [1] 15.6 μM Ac-YVAD-CHO inhibited NO-induced PARP cleavage and reduced NO-induced apoptosis in SNAP-treated thymocytes. [2]
In vivo	30 mg/kg intraperitoneal injection of Ac-YVAD-CHO inhibited IL-1β levels in the blood of P. acnes sensitized mice. [1] Intrastriatal infusion of 2-8 μg Ac-YVAD-CHO attenuated quinolinic acid (QA)-induced apoptosis in rat striatum. [3]
Synonyms	L-709049, L709049, L 709049

Chemical Properties

Molecular Weight	492.52
Formula	C₂₃H₃₂N₄O₈
Cas No.	143313-51-3
Smiles	[C@@H](NC([C@H](CC1=CC=C(O)C=C1)NC(C)=O)=O)(C(N[C@H](C(N[C@@H](CC(O)=O)C=O)=O)C)=O)C(C)C
Relative Density.	1.276 g/cm3 (Predicted)
Sequence	Ac-Tyr-Val-Ala-Asp-al
Sequence Short	YVAD-CHO

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 50 mg/mL (101.52 mM), Sonication is recommended.

DMSO: 2 mg/mL (4.06 mM), Sonication is recommended.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	2.0304 mL	10.1519 mL	20.3037 mL	101.5187 mL

H2O

	1mg	5mg	10mg	50mg
5 mM	0.4061 mL	2.0304 mL	4.0607 mL	20.3037 mL
10 mM	0.2030 mL	1.0152 mL	2.0304 mL	10.1519 mL
20 mM	0.1015 mL	0.5076 mL	1.0152 mL	5.0759 mL
50 mM	0.0406 mL	0.2030 mL	0.4061 mL	2.0304 mL
100 mM	0.0203 mL	0.1015 mL	0.2030 mL	1.0152 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc